Pattern dystrophies in patients treated with deferoxamine: report of two cases and review of the literature
| العنوان: | Pattern dystrophies in patients treated with deferoxamine: report of two cases and review of the literature |
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| المؤلفون: | Elli V. Kostopoulou, Olga E Makri, Constantine D. Georgakopoulos, Foteini Tsapardoni |
| المصدر: | BMC Ophthalmology BMC Ophthalmology, Vol 18, Iss 1, Pp 1-9 (2018) |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pediatrics, Retinal Disorder, Thalassemia, Siderophores, Case Report, Hemosiderosis, Deferoxamine, Infusions, Subcutaneous, Retina, Drug toxicity, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, Internal medicine, Electroretinography, medicine, Humans, Chelation therapy, Dose Modification, Hematology, business.industry, Retinal Degeneration, General Medicine, Middle Aged, medicine.disease, Pattern dystrophy, Discontinuation, Ophthalmology, lcsh:RE1-994, 030221 ophthalmology & optometry, Female, sense organs, business, Tomography, Optical Coherence, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Background Deferoxamine (DFO) is one of the most commonly used chelation treatments for transfusional hemosiderosis. Pattern dystrophies constitute a distinct entity of retinal disorders that has been occasionally identified in association with deferoxamine. Case presentation We report two cases of bilateral macular pattern dystrophy in transfusion dependent patients undergoing chronic chelation therapy with deferoxamine due to thalassemias. Our patients were evaluated with multimodal imaging and the results are presented. Both patients had normal cone and rod responses in the full-field electroretinogram and continued the prescribed chelation therapy, after hematology consult. The patients were followed up every 3 months for 2 and 4 years respectively for possible deterioration. Their best corrected visual acuity remained stable with no anatomic change on Optical Coherence Tomography findings. Conclusion Multimodal imaging of our patients allowed a better evaluation and possibly earlier detection of the DFO-related changes. Screening and close follow up of patients under chronic chelating therapy is important in order to promptly diagnose and manage possible toxicity either with discontinuation of the offending agent or dose modification. |
| تدمد: | 1471-2415 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee8a2653221453fc6845392f75cbfafTest https://doi.org/10.1186/s12886-018-0911-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ee8a2653221453fc6845392f75cbfaf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712415 |
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