التفاصيل البيبلوغرافية
العنوان:
Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations
المؤلفون:
Brendan J. Keating , Rudaynah Al Ali , Cyril Cyrus , Hatem O. Qutub , Shahanas Chathoth , Brian Kim-Mozeleski , Chittibabu Vatte , Amein Al Ali , Yun Li , Abdullah M. Al-Rubaish , Samir H Al-Mueilo , Khaled R. Alkharsah , Fahad Al-Muhanna , Matthew B. Lanktree
المصدر:
BMC Nephrology
بيانات النشر:
BioMed Central, 2018.
سنة النشر:
2018
مصطلحات موضوعية:
0301 basic medicine , Male , 030232 urology & nephrology , Genome-wide association study , SLC7A9 , Logistic regression , urologic and male genital diseases , lcsh:RC870-923 , MYH9 , Genetic biomarkers , 0302 clinical medicine , Risk Factors , Chronic kidney disease , Genotype , Cholecalciferol , Molecular Motor Proteins , Microfilament Proteins , CST3 , Middle Aged , Nephrology , Cohort , Female , Research Article , Glomerular Filtration Rate , Adult , medicine.medical_specialty , Saudi Arabia , Renal function , SNP , Polymorphism, Single Nucleotide , 03 medical and health sciences , Internal medicine , medicine , Vitamin D and neurology , Humans , Cystatin C , Renal Insufficiency, Chronic , Alleles , Aged , Myosin Heavy Chains , business.industry , SHROOM3 , medicine.disease , lcsh:Diseases of the genitourinary system. Urology , Minor allele frequency , Fibroblast Growth Factors , Fibroblast Growth Factor-23 , 030104 developmental biology , Case-Control Studies , Amino Acid Transport Systems, Basic , business , Kidney disease
الوصف:
Background Genome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular filtration rate (eGFR). A panel of eight variants were selected to evaluate their association and prevalence in a Saudi Arabian patient cohort with chronic kidney disease (CKD). Methods Eight genetic variants in four genes (SHROOM3, MYH9, SLC7A9, and CST3) were genotyped in 160 CKD patients and 189 ethnicity-matched healthy controls. Genetic variants were tested for association with the development of CKD (eGFR
اللغة:
English
تدمد:
1471-2369
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb643827947207bcc5650c23a797150dTest http://europepmc.org/articles/PMC5905143Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....fb643827947207bcc5650c23a797150d
قاعدة البيانات:
OpenAIRE
