SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021

التفاصيل البيبلوغرافية
العنوان: SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021
المؤلفون: Jacquline Msefula, Gaurav Kwatra, Kondwani C Jambo, Andrew Likaka, Adamson S Muula, Zanele Makhado, Brewster Moyo, Penny L. Moore, Jonathan Mandolo, Aubrey Samon, Nonkululeko Mzindle, Thom Mfune, Thandeka Moyo-Gwete, Comfort Brown, Marc Henrion, Newton Kalata, Todd D. Swarthout, Frances Ayres, Bridon M'baya, Robert S. Heyderman, Neil French, Natasha Nsamala, Thopisang Motlou
المصدر: BMC Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
BMC Medicine
بيانات النشر: BMC, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Malawi, COVID-19 Vaccines, Blood transfusion, wh_460, Cross-sectional study, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, Population, Seroprevalence, wa_395, Antibodies, Viral, Blood donors, Herd immunity, Seroepidemiologic Studies, wc_506, Pandemic, wc_505, medicine, Humans, education, Pandemics, education.field_of_study, business.industry, SARS-CoV-2, COVID-19, General Medicine, Cross-Sectional Studies, qw_160, Medicine, Rural area, business, Research Article, Demography
الوصف: Background By August 2021, the COVID-19 pandemic has been less severe in sub-Saharan Africa than elsewhere. In Malawi, there have been three subsequent epidemic waves. We therefore aimed to describe the dynamics of SARS-CoV-2 exposure in Malawi. Methods We measured the seroprevalence of anti-SARS-CoV-2 antibodies amongst randomly selected blood transfusion donor sera in Malawi from January 2020 to July 2021 using a cross-sectional study design. In a subset, we also assessed in vitro neutralisation against the original variant (D614G WT) and the Beta variant. Results A total of 5085 samples were selected from the blood donor database, of which 4075 (80.1%) were aged 20–49 years. Of the total, 1401 were seropositive. After adjustment for assay characteristics and applying population weights, seropositivity reached peaks in October 2020 (18.5%) and May 2021 (64.9%) reflecting the first two epidemic waves. Unlike the first wave, both urban and rural areas had high seropositivity in the second wave, Balaka (rural, 66.2%, April 2021), Blantyre (urban, 75.6%, May 2021), Lilongwe (urban, 78.0%, May 2021), and Mzuzu (urban, 74.6%, April 2021). Blantyre and Mzuzu also show indications of the start of a third pandemic wave with seroprevalence picking up again in July 2021 (Blantyre, 81.7%; Mzuzu, 71.0%). More first wave sera showed in vitro neutralisation activity against the original variant (78% [7/9]) than the beta variant (22% [2/9]), while more second wave sera showed neutralisation activity against the beta variant (75% [12/16]) than the original variant (63% [10/16]). Conclusion The findings confirm extensive SARS-CoV-2 exposure in Malawi over two epidemic waves with likely poor cross-protection to reinfection from the first on the second wave. The dynamics of SARS-CoV-2 exposure will therefore need to be taken into account in the formulation of the COVID-19 vaccination policy in Malawi and across the region. Future studies should use an adequate sample size for the assessment of neutralisation activity across a panel of SARS-CoV-2 variants of concern/interest to estimate community immunity.
وصف الملف: application/pdf
اللغة: English
تدمد: 1741-7015
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509a86e9a7a30fcf623a2bd7c137cb9dTest
https://doaj.org/article/6dc34a3e1a654cbb8c7df487c319c32bTest
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....509a86e9a7a30fcf623a2bd7c137cb9d
قاعدة البيانات: OpenAIRE