Colon capsule endoscopy versus CT colonography in FIT-positive colorectal cancer screening subjects: a prospective randomised trial—the VICOCA study
| العنوان: | Colon capsule endoscopy versus CT colonography in FIT-positive colorectal cancer screening subjects: a prospective randomised trial—the VICOCA study |
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| المؤلفون: | Jaume Grau, Gloria Fernández-Esparrach, Miquel Serra-Burriel, Francesc Balaguer, María López-Cerón, Josep Llach, Cristina Rodríguez de Miguel, Maria Pellise, Cristina Romero, Begoña González-Suárez, Angels Pozo, Antoni Castells, Isis K. Araujo, Oriol Sendino, Angels Ginès, Andrés Cárdenas, Henry Córdova, Maria Vila-Casadesús, Juan Ramón Ayuso, Anna Serradesanferm, David Flores, Mario Pagés |
| المصدر: | BMC Medicine, Vol 18, Iss 1, Pp 1-11 (2020) BMC Medicine Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Colorectal cancer, education, Colon capsule endoscopy, Colonoscopy, lcsh:Medicine, Capsule Endoscopy, Gastroenterology, law.invention, Colorectal cancer screening, 03 medical and health sciences, 0302 clinical medicine, Capsule endoscopy, law, Positive predicative value, Internal medicine, CT colonography, medicine, Humans, Mass Screening, Prospective Studies, Endoscòpia, Càncer, neoplasms, Early Detection of Cancer, Cancer, medicine.diagnostic_test, Crc screening, business.industry, Neoplastic lesion, lcsh:R, Colonoscòpia, Endoscopy, General Medicine, Middle Aged, medicine.disease, digestive system diseases, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business, Colonography, Computed Tomographic, Research Article |
| الوصف: | Background Colon capsule endoscopy (CCE) and CT colonography (CTC) are minimally invasive techniques for colorectal cancer (CRC) screening. Our objective is to compare CCE and CTC for the identification of patients with colorectal neoplasia among participants in a CRC screening programme with positive faecal immunochemical test (FIT). Primary outcome was to compare the performance of CCE and CTC in detecting patients with neoplastic lesions. Methods The VICOCA study is a prospective, single-centre, randomised trial conducted from March 2014 to May 2016; 662 individuals were invited and 349 were randomised to CCE or CTC before colonoscopy. Endoscopists were blinded to the results of CCE and CTC. Results Three hundred forty-nine individuals were included: 173 in the CCE group and 176 in the CTC group. Two hundred ninety individuals agreed to participate: 147 in the CCE group and 143 in the CTC group. In the intention-to-screen analysis, sensitivity, specificity and positive and negative predictive values for the identification of individuals with colorectal neoplasia were 98.1%, 76.6%, 93.7% and 92.0% in the CCE group and 64.9%, 95.7%, 96.8% and 57.7% in the CTC group. In terms of detecting significant neoplastic lesions, the sensitivity of CCE and CTC was 96.1% and 79.3%, respectively. Detection rate for advanced colorectal neoplasm was higher in the CCE group than in the CTC group (100% and 93.1%, respectively; RR = 1.07; p = 0.08). Both CCE and CTC identified all patients with cancer. CCE detected more patients with any lesion than CTC (98.6% and 81.0%, respectively; RR = 1.22; p = 0.002). Conclusion Although both techniques seem to be similar in detecting patients with advanced colorectal neoplasms, CCE is more sensitive for the detection of any neoplastic lesion. Trial registration ClinicalTrials.gov Identifier: NCT02081742. Registered: September 16, 2013. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1741-7015 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f4becd47a47745001e70c7ebf49113Test http://link.springer.com/article/10.1186/s12916-020-01717-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7f4becd47a47745001e70c7ebf49113 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417015 |
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