دورية أكاديمية
neoANT-HILL: an integrated tool for identification of potential neoantigens
| العنوان: | neoANT-HILL: an integrated tool for identification of potential neoantigens |
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| المؤلفون: | Ana Carolina M. F. Coelho, André L. Fonseca, Danilo L. Martins, Paulo B. R. Lins, Lucas M. da Cunha, Sandro J. de Souza |
| المصدر: | BMC Medical Genomics, Vol 13, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Internal medicine LCC:Genetics |
| مصطلحات موضوعية: | Neoantigens, Cancer, Immunogenomic analyses, Internal medicine, RC31-1245, Genetics, QH426-470 |
| الوصف: | Abstract Background Cancer neoantigens have attracted great interest in immunotherapy due to their capacity to elicit antitumoral responses. These molecules arise from somatic mutations in cancer cells, resulting in alterations on the original protein. Neoantigens identification remains a challenging task due largely to a high rate of false-positives. Results We have developed an efficient and automated pipeline for the identification of potential neoantigens. neoANT-HILL integrates several immunogenomic analyses to improve neoantigen detection from Next Generation Sequence (NGS) data. The pipeline has been compiled in a pre-built Docker image such that minimal computational background is required for download and setup. NeoANT-HILL was applied in The Cancer Genome Atlas (TCGA) melanoma dataset and found several putative neoantigens including ones derived from the recurrent RAC1:P29S and SERPINB3:E250K mutations. neoANT-HILL was also used to identify potential neoantigens in RNA-Seq data with a high sensitivity and specificity. Conclusion neoANT-HILL is a user-friendly tool with a graphical interface that performs neoantigens prediction efficiently. neoANT-HILL is able to process multiple samples, provides several binding predictors, enables quantification of tumor-infiltrating immune cells and considers RNA-Seq data for identifying potential neoantigens. The software is available through github at https://github.com/neoanthill/neoANT-HILLTest. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1755-8794 83806245 |
| العلاقة: | http://link.springer.com/article/10.1186/s12920-020-0694-1Test; https://doaj.org/toc/1755-8794Test |
| DOI: | 10.1186/s12920-020-0694-1 |
| الوصول الحر: | https://doaj.org/article/bea0fd838062458d8edc14172abf2fe2Test |
| رقم الانضمام: | edsdoj.bea0fd838062458d8edc14172abf2fe2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17558794 83806245 |
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| DOI: | 10.1186/s12920-020-0694-1 |