التفاصيل البيبلوغرافية
| العنوان: |
Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis. |
| المؤلفون: |
Xie, Zhengjun1 (AUTHOR) zhj_xie@hotmail.com, Peng, Wei1 (AUTHOR), Li, Qiuhua1 (AUTHOR), Cheng, Wei1 (AUTHOR), Zhao, Xin1 (AUTHOR) |
| المصدر: |
BMC Medical Genomics. 9/18/2021, Vol. 14 Issue 1, p1-11. 11p. |
| مصطلحات موضوعية: |
*LEUKEMIA, *META-analysis, *GENETIC models, *ETHNICITY, POPULATION of China |
| مصطلحات جغرافية: |
CHINA |
| الشركة/الكيان: |
GOOGLE Inc. GOOG |
| مستخلص: |
Background: Presently, whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial. Because of this reason, the objective of current study is to explore whether XRCC3 Thr241Met polymorphism confers risk to leukemia. Methods: Two independent authors systematically and comprehensively searched Pubmed, Embase, the Cochrane library, Google academic, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021. Results: Overall, significant associations between leukemia risk and XRCC3 Thr241Met polymorphism were found in Caucasian population by allele contrast (T vs. C: OR 1.20, 95% CI 1.02–1.40), homozygote comparison (TT vs. CC: OR 1.35, 95% CI 1.05–1.73), and recessive genetic model (TT vs. TC/CC: OR 1.31, 95% CI 1.04–1.64). Conclusions: The present meta-analysis suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for leukemia in Caucasian population. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
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