Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction
| العنوان: | Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction |
|---|---|
| المؤلفون: | Bo Gregers Winkel, Lisette Okkels Jensen, Christine M. Albert, Charlotte Glinge, Javad Jabbari, Bjarke Risgaard, Christian Juhl Terkelsen, Reza Jabbari, Stefan M. Sattler, Hans-Henrik Tilsted, Stig Haunsø, Thomas Engstrøm, Jacob Tfelt-Hansen, Mikkel Hougaard |
| المصدر: | BMC Medical Genetics Jabbari, R, Jabbari, J, Glinge, C, Risgaard, B, Sattler, S, Winkel, B G, Terkelsen, C J, Tilsted, H-H, Jensen, L O, Hougaard, M, Haunsø, S, Engstrøm, T, Albert, C M & Tfelt-Hansen, J 2017, ' Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction ', B M C Medical Genetics, vol. 18, no. 1, 138 . https://doi.org/10.1186/s12881-017-0497-1Test BMC Medical Genetics, Vol 18, Iss 1, Pp 1-6 (2017) Jabbari, R, Jabbari, J, Glinge, C, Risgaard, B, Sattler, S, Winkel, B G, Terkelsen, C J, Tilsted, H H, Jensen, L O, Hougaard, M, Haunsø, S, Engstrøm, T, Albert, C M & Tfelt-Hansen, J 2017, ' Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction ', BMC Medical Genetics, vol. 18, 138 . https://doi.org/10.1186/s12881-017-0497-1Test Jabbari, R, Jabbari, J, Glinge, C, Risgaard, B, Sattler, S, Winkel, B G, Terkelsen, C J, Tilsted, H-H, Jensen, L O, Hougaard, M, Haunsø, S, Engstrøm, T, Albert, C M & Tfelt-Hansen, J 2017, ' Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction ', B M C Medical Genetics, vol. 18, no. 1, pp. 138 . https://doi.org/10.1186/s12881-017-0497-1Test |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, ST Elevation Myocardial Infarction/diagnosis, Infarction, 030204 cardiovascular system & hematology, Sudden cardiac death, 0302 clinical medicine, Risk Factors, Atrial Fibrillation, Medicine, Myocardial infarction, Prospective Studies, Prospective cohort study, Genetics (clinical), Age Factors, Atrial fibrillation, Middle Aged, 3. Good health, ST-elevation myocardial infarction, Ventricular Fibrillation, Cardiology, Female, Research Article, medicine.medical_specialty, Ventricular Fibrillation/diagnosis, lcsh:Internal medicine, lcsh:QH426-470, Sudden death, Polymorphism, Single Nucleotide, 03 medical and health sciences, Sex Factors, Internal medicine, Genetic model, Atrial Fibrillation/diagnosis, Genetics, Journal Article, Humans, cardiovascular diseases, Ventricular fibrillation, lcsh:RC31-1245, Aged, Models, Genetic, business.industry, Single nucleotide polymorphisms, medicine.disease, lcsh:Genetics, 030104 developmental biology, Logistic Models, Genetic Loci, Case-Control Studies, ST Elevation Myocardial Infarction, business |
| الوصف: | BACKGROUND: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI).METHODS: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry.RESULTS: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p CONCLUSION: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-2350 |
| DOI: | 10.1186/s12881-017-0497-1 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca12868d1d6a8ac4fe9078b55ea9cd6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9ca12868d1d6a8ac4fe9078b55ea9cd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712350 |
|---|---|
| DOI: | 10.1186/s12881-017-0497-1 |