Prognostic value of pro-adrenomedullin and copeptin in acute infective endocarditis
| العنوان: | Prognostic value of pro-adrenomedullin and copeptin in acute infective endocarditis |
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| المؤلفون: | Maria Paola Ursi, Roberto Andini, Emanuele Durante-Mangoni, Luigi Atripaldi, Rosa Zampino, Domenico Iossa, Rosa Molaro, Silvia Leonardi, Oriana Fabrazzo, Lorenzo Bertolino |
| المساهمون: | Zampino, R., Iossa, D., Ursi, M. P., Bertolino, L., Andini, R., Molaro, R., Fabrazzo, O., Leonardi, S., Atripaldi, L., Durante-Mangoni, E. |
| المصدر: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Protein Precursor, Organ dysfunction, Disease, 030204 cardiovascular system & hematology, Procalcitonin, Adrenomedullin, 0302 clinical medicine, Retrospective Studie, Endocarditi, Hospital Mortality, Aged, 80 and over, Endocarditis, Glycopeptides, Heart valve disease, Middle Aged, Staphylococcal Infections, Prognosis, Infectious Diseases, C-Reactive Protein, Infective endocarditis, Biomarker (medicine), Female, medicine.symptom, Human, Research Article, Adult, medicine.medical_specialty, Adolescent, Prognosi, Heart failure, Glycopeptide, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, Copeptin, Internal medicine, Streptococcal Infections, Streptococcal Infection, medicine, Humans, lcsh:RC109-216, Protein Precursors, Mortality, Staphylococcal Infection, Aged, Retrospective Studies, business.industry, 030208 emergency & critical care medicine, Retrospective cohort study, Biomarker, Endocarditis, Bacterial, medicine.disease, business, Biomarkers, Kidney disease |
| الوصف: | Background Infective endocarditis (IE) is a life-threatening disease whose prognosis is often difficult to predict based on clinical data. Biomarkers have been shown to favorably affect disease management in a number of cardiac disorders. Aims of this retrospective study were to assess the prognostic role of procalcitonin (PCT), pro-adrenomedullin (pro-ADM) and copeptin in IE and their relation with disease characteristics and the traditional biomarker C-reactive protein (CRP). Methods We studied 196 patients with definite IE. Clinical, laboratory and echocardiography parameters were analyzed, with a focus on co-morbidities. PCT, pro-ADM and copeptin were measured on stored plasma samples obtained on admission during the acute phase of the disease. Results Pro-ADM and copeptin were significantly higher in older patients and associated with prior chronic kidney disease. Pro-ADM was an independent predictor of hospital mortality (OR 3.29 [95%C.I. 1.04–11.5]; p = 0.042) whilst copeptin independently predicted 1-year mortality (OR 2.55 [95%C.I. 1.18–5.54]; p = 0.017). A high PCT value was strictly tied with S. aureus etiology (p = 0.001). CRP was the only biomarker associated with embolic events (p = 0.003). Conclusions Different biomarkers correlate with distinct IE outcomes. Pro-ADM and copeptin may signal a worse prognosis of IE on admission to the hospital and could be used to identify patients who need more aggressive treatment. CRP remains a low-cost marker of embolic risk. A high PCT value should suggest S. aureus etiology. |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75d271771b20d10ae59e6c5096e4a57Test https://pubmed.ncbi.nlm.nih.gov/33413127Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f75d271771b20d10ae59e6c5096e4a57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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