التفاصيل البيبلوغرافية
| العنوان: |
Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report. |
| المؤلفون: |
Vidal, Charles1 charlevidal@orange.fr, Moulin, Florence2 Florence.moulin@aphp.fr, Nassif, Xavier1 Xavier.nassif@inserm.fr, Galmiche, Louise3 louise.galmiche-rolland@aphp.fr, Borgel, Delphine4 delphine.borgel@aphp.fr, Charbit, Alain5 alain.charbit@inserm.fr, Picard, Capucine6,7 capucine.picard@aphp.fr, Mira, Jean-Paul8,9 jean-paul.mira@aphp.fr, Lortholary, Olivier10 Olivier.lortholary@aphp.fr, Jamet, Anne1,5 anne.jamet@inserm.fr, Toubiana, Julie9,11 julie.toubiana@aphp.fr |
| المصدر: |
BMC Infectious Diseases. 4/3/2019, Vol. 19 Issue 1, pN.PAG-N.PAG. 1p. 1 Color Photograph, 2 Charts. |
| مصطلحات موضوعية: |
*STAPHYLOCOCCAL diseases, *STAPHYLOCOCCUS aureus, *GANGRENE, *MOLECULAR cloning, *VASCULITIS, *IMMUNE response, *ANTIBIOTICS, *LEG surgery, *AMPUTATION, *BRAIN, *CEFOTAXIME, *CLINDAMYCIN, *MAGNETIC resonance imaging, *METHICILLIN, *SEPTIC shock, *DISEASE complications, *PHARMACODYNAMICS |
| مستخلص: |
Background: Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness may be a consequence of both microbial factors and variability of the host immune response.Case Presentation: A 14-years old child developed limb ischemia with gangrene following S. aureus bloodstream infection. Histopathology revealed medium-sized arterial vasculitis. The causing strain belonged to the emerging clone CC1-MSSA and numerous pathogenesis-related genes were identified. Patient's genotyping revealed functional variants associated with severe infections. A combination of virulence and host factors might explain this unique severe form of staphylococcal disease.Conclusion: A combination of virulence and genetic host factors might explain this unique severe form of staphylococcal disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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