Seroprevalence of Immunoglobulin G antibodies against pertussis toxin among asymptomatic medical students in the west of Iran: a cross sectional study
| العنوان: | Seroprevalence of Immunoglobulin G antibodies against pertussis toxin among asymptomatic medical students in the west of Iran: a cross sectional study |
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| المؤلفون: | Mohammad-Ali Seif-Rabiei, Javad Moghimi, Seyyed Hamid Hashemi, Mehrdad Hajilooi, Mahnaz Bolandi, Mitra Ranjbar |
| المصدر: | BMC Infectious Diseases BMC Infectious Diseases, Vol 9, Iss 1, p 58 (2009) |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Students, Medical, Whooping Cough, Population, Prevalence, Booster dose, Iran, lcsh:Infectious and parasitic diseases, Young Adult, Seroepidemiologic Studies, Internal medicine, Medicine, Seroprevalence, Humans, lcsh:RC109-216, education, Whooping cough, Pertussis Vaccine, education.field_of_study, business.industry, Vaccination, Respiratory infection, medicine.disease, Antibodies, Bacterial, Infectious Diseases, Cross-Sectional Studies, Pertussis Toxin, Immunoglobulin G, Immunology, Pertussis vaccine, Population study, Female, business, medicine.drug, Research Article |
| الوصف: | BackgroundPertussis is a highly communicable, vaccine-preventable respiratory infection. Immune response against this disease can be induced by infection or vaccination. Protection after childhood vaccination is minimal after ten years. Our aim was to assess pertussis immunity state in a population of healthy young medical students.MethodsIn this seroepidemiological survey, blood samples were obtained from 163 first-year medical students in Hamedan University, Iran. Serum level of IgG against pertussis toxin (IgG-PT) was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. For qualitative assessment, IgG-PT levels more than 24 unit (U)/ml were considered positive. Data was analysed qualitatively and quantitatively considering gender and age groups.ResultsThere were 83 males and 80 females, with a mean age of 19.48 years, Prevalence of IgG-PT was 47.6% with mean level of 71.7 u/ml (95% confidence interval: 68.1–75.3). No statistically significant difference was observed with respect to sero-positivity of IgG-PT between males and females (45 cases (54%) vs. 34 cases (42%); P = 0.06). Mean IgG-PT levels in males and females were 84 U/ml and 58.8 U/ml, respectively (P = 0.91).ConclusionA considerable proportion of our study population with a positive history of childhood vaccination for pertussis was not serologically immune to pertussis. A booster dose of acellular pertussis vaccine may be indicated in Iranian, medical students regarding their serologic conditions and outstanding role in health care systems. |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abbc8665001a24178c8ac40c36ee823Test https://pubmed.ncbi.nlm.nih.gov/19426546Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4abbc8665001a24178c8ac40c36ee823 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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