Sexually transmitted infections and use of contraceptives in women living with HIV in Denmark – the SHADE cohort
| العنوان: | Sexually transmitted infections and use of contraceptives in women living with HIV in Denmark – the SHADE cohort |
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| المؤلفون: | Jesper Bonde, Kristina Thorsteinsson, Lars Nørregård Nielsen, Merete Storgaard, Gitte Pedersen, Anne-Mette Lebech, Steen Ladelund, Isik Somuncu Johansen, Frederikke Falkencrone Rönsholt, Henrik Westh, Terese L. Katzenstein, Niels Obel |
| المصدر: | Thorsteinsson, K, Ladelund, S, Storgaard, M, Falkencrone Rønsholt, F, Johansen, I S, Pedersen, G, Nielsen, L N, Bonde, J, Westh, H, Obel, N, Katzenstein, T L & Lebech, A-M 2016, ' Sexually transmitted infections and use of contraceptives in women living with HIV in Denmark-the SHADE cohort ', BMC Infectious Diseases, vol. 16, no. 81 . https://doi.org/10.1186/s12879-016-1412-7Test Thorsteinsson, K, Ladelund, S, Storgaard, M, Rønsholt, F F, Johansen, I S, Pedersen, G, Nielsen, L N, Bonde, J, Westh, H, Obel, N, Katzenstein, T L & Lebech, A-M 2016, ' Sexually transmitted infections and use of contraceptives in women living with HIV in Denmark-the SHADE cohort ', B M C Infectious Diseases, vol. 16, pp. 81 . https://doi.org/10.1186/s12879-016-1412-7Test BMC Infectious Diseases Thorsteinsson, K, Ladelund, S, Storgaard, M, Rønsholt, F F, Johansen, I S, Pedersen, G, Nielsen, L N, Bonde, J, Westh, H, Obel, N, Katzenstein, T L & Lebech, A-M 2016, ' Sexually transmitted infections and use of contraceptives in women living with HIV in Denmark : the SHADE cohort ', BMC Infectious Diseases, vol. 16, 81 . https://doi.org/10.1186/s12879-016-1412-7Test |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Sexually Transmitted Diseases, Bacterial, 0301 basic medicine, Sexual activity, Denmark, Herpesvirus 2, Human, HIV Infections, Hormonal contraception, Herpesvirus 1, Human, medicine.disease_cause, law.invention, Condoms, 0302 clinical medicine, law, Prevalence, Condom use, Prospective Studies, 030212 general & internal medicine, education.field_of_study, Obstetrics, Research Support, Non-U.S. Gov't, virus diseases, Middle Aged, Contraceptive use, Multicenter Study, Contraception, Infectious Diseases, Family planning, Cohort, Screening, Female, Research Article, Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Observational Study, condom use, Young Adult, 03 medical and health sciences, Condom, Sexually transmitted infections, Journal Article, medicine, Women living with HIV, Humans, education, Gynecology, Pregnancy, business.industry, Herpes Simplex, medicine.disease, HIV-1, Syphilis, Chlamydia trachomatis, business, Follow-Up Studies |
| الوصف: | Background No Danish guidelines for screening of sexually transmitted infections (STIs) in women living with HIV (WLWH) exist, except for annual syphilis testing. Drug-drug interaction between hormonal contraceptives and some types of highly active antiretroviral therapy (HAART) occurs. We assessed prevalence of STIs, contraceptive choices and predictors of condom use in a cohort of WLWH in Denmark. Methods WLWH consecutively enrolled during their outpatient visits from 2011 to 2012. Gynaecological examination and an interview were performed at entry and 6-month follow-up. Inclusion criteria were HIV-1 infection and ≥ 18 years of age. Exclusion criteria were pregnancy, alcohol- or drug abuse impeding adherence to the protocol. At entry, participants were tested (and where appropriate, treated according to guidelines) for Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, and herpes simplex (HSV-1 and HSV-2). At follow-up, predictors of condom use were estimated in sexually active WLWH. Results In total, 334 of the 1,392 eligible WLWH in Denmark were included (median age and HIV duration: 42.5 and 11.3 years). Chlamydia trachomatis was present in four individuals (1 %), and six (2 %) tested positive for HSV-2 by PCR. None were positive for Neisseria gonorrhoeae, HSV-1 or had active syphilis. At follow-up, 252 (76 %) participated; 168 (70 %) were sexually active. Contraceptives were used by 124 (75 %); condoms were preferred (62 %). Having an HIV-negative partner predicted condom use (adjusted OR 3.89 (95 %CI 1.49-10.11)). In the group of participants of reproductive age without pregnancy desires 13 % used no birth-control. Possible drug-drug interaction between hormonal contraceptives and HAART was found in 13/14 WLWH receiving both kinds of medication. Conclusion The prevalence of STIs in WLWH in Denmark was low. The need for annual STI screening is questionable. Condoms were preferred contraceptives, especially in WLWH with an HIV-negative partner. In this cohort, 13 % of WLWH of reproductive age were at risk of unintended pregnancies due to lack of birth-control. Finally, in the subgroup of WLWH receiving both hormonal contraceptives and HAART possible drug-drug interactions could occur. Electronic supplementary material The online version of this article (doi:10.1186/s12879-016-1412-7) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6366128ba927d7666320d257268cc51dTest https://doi.org/10.1186/s12879-016-1412-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6366128ba927d7666320d257268cc51d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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