Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis
| العنوان: | Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis |
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| المؤلفون: | Won-Il Choi, Diana Qama, Kun Young Kwon |
| المصدر: | BMC Immunology, Vol 13, Iss 1, p 45 (2012) BMC Immunology |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, lcsh:Immunologic diseases. Allergy, Allergy, Pathology, medicine.medical_specialty, Tuberculosis, T-Lymphocytes, Immunology, CD4-CD8 Ratio, Tuberculous pleural effusion, Immune system, T-Lymphocyte Subsets, Pulmonary tuberculosis, Parenchyma, Humans, Medicine, Lung, Th1-Th2 Balance, Tuberculosis, Pulmonary, Tumor necrosis factor α, business.industry, Extrapulmonary tuberculosis, Immunity, Middle Aged, respiratory system, medicine.disease, respiratory tract diseases, Tumor necrosis factor-α, Pleural Effusion, Cytokines, Female, Interferon-γ, Vascular endothelial growth factor, business, lcsh:RC581-607, Research Article |
| الوصف: | Background Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients without pulmonary tuberculosis. Methods Patients with any evidence of pulmonary tuberculosis, either from radiologic or bacteriologic evaluation, were excluded. Bronchoalveolar lavage fluid (BALF) was collected from 10 newly diagnosed, untreated, HIV-negative TPE patients and 10 healthy controls. We analyzed T-lymphocyte subpopulations and measured 10 cytokines in BALF. Cytokine levels in BALF were standardised using urea. Results The concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and the CD4+/CD8+ ratio of T-lymphocytes were significantly higher in TPE patients without pulmonary tuberculosis than in the controls. Of the cytokines measured in BALF, VEGF showed the highest concentration. No difference was observed in T-helper type 2 cytokines between the 2 groups. Conclusion There were significant immune responses and increases in IFN-γ, TNF-α, and VEGF in the lung parenchyma of TPE patients without pulmonary tuberculosis. This result suggests that TPE may induce a significant immune response in lung parenchyma. |
| اللغة: | English |
| تدمد: | 1471-2172 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6fd66599890fb916cdd43ab1559660Test http://www.biomedcentral.com/1471-2172/13/45Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1e6fd66599890fb916cdd43ab1559660 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712172 |
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