التفاصيل البيبلوغرافية
| العنوان: |
Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp. |
| المؤلفون: |
Mandal, Roland Nathan, Ke, Jing, Kanika, Nusrat Hasan, Wang, Fuyan, Wang, Jun, Wang, Chenghui |
| المصدر: |
BMC Genomics; 7/2/2024, Vol. 25 Issue 1, p1-13, 13p |
| مصطلحات موضوعية: |
GENE regulatory networks, CARP, HUMAN skin color, NEUROTRANSMITTERS, ENVIRONMENTAL health, MELANOGENESIS |
| مستخلص: |
Background: Neither a TYRP1-mediated highly conserved genetic network underlying skin color towards optimum defense nor the pathological tendency of its mutation is well understood. The Oujiang Color Common Carp (Cyprinus carpio var. color) as a model organism, offering valuable insights into genetics, coloration, aquaculture practices, and environmental health. Here, we performed a comparative skin transcriptome analysis on TYRP1 mutant and wild fishes by applying a conservative categorical approach considering different color phenotypes. Results: Our results reveal that an unusual color phenotype may be sensitized with TYRP1 mutation as a result of upregulating several genes related to an anti-inflammatory autoimmune system in response to the COMT-mediated catecholamine neurotransmitters in the skin. Particularly, catecholamines-derived red/brown, red with blue colored membrane attack complex, and brown/grey colored reduced eumelanin are expected to be aggregated in the regenerated cells. Conclusions: It is, thus, concluded that the regenerated cells with catecholamines, membrane attack complex, and eumelanin altogether may contribute to the formation of the unusual (coffee-like) color phenotype in TYRP1 mutant. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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