دورية أكاديمية
An immunogenic cell death-related gene expression signature in predicting prognosis of pancreatic ductal adenocarcinoma
| العنوان: | An immunogenic cell death-related gene expression signature in predicting prognosis of pancreatic ductal adenocarcinoma |
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| المؤلفون: | Xiaobo Wang, Tianxiang Ren, Chuting Liao, Yong Xie, Jing Cao |
| المصدر: | BMC Genomics, Vol 25, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | Immunogenic cell death, Pancreatic ductal adenocarcinoma, Tumor microenvironment, Immune infiltration, Prognosis model, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Immunogenic cell death (ICD) has been identified as regulated cell death, which is sufficient to activate the adaptive immune response. This study aimed to research ICD-related genes and create a gene model to predict pancreatic ductal adenocarcinoma (PAAD) patients’ prognosis. Methods The RNA sequencing and clinical data were downloaded from the TGCA and GEO databases. The PAAD samples were classified into two subtypes based on the expression levels of ICD-related genes using consensus clustering. Based on the differentially expressed genes (DEGs), a prognostic scoring model was constructed using LASSO regression and Cox regression, and the scoring model was used to predict the prognosis of PAAD patients. Moreover, colony formation assay was performed to confirm the prognostic value of those genes. Results We identified two ICD cluster by consensus clustering, and found that the the ICD-high group was closely associated with immune-hot phenotype, favorable clinical outcomes. We established an ICD-related prognostic model which can predict the prognosis of pancreatic ductal adenocarcinoma. Moreover, depletion of NT5E, ATG5, FOXP3, and IFNG inhibited the colony formation ability of pancreatic cancer cell. Conclusion We identified a novel classification for PAAD based on the expression of ICD-related genes, which may provide a potential strategy for therapeutics against PAAD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 |
| العلاقة: | https://doaj.org/toc/1471-2164Test |
| DOI: | 10.1186/s12864-024-10106-7 |
| الوصول الحر: | https://doaj.org/article/ff1cbb0c9c4349b18fc9528e20bcc2f5Test |
| رقم الانضمام: | edsdoj.ff1cbb0c9c4349b18fc9528e20bcc2f5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14712164 |
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| DOI: | 10.1186/s12864-024-10106-7 |