التفاصيل البيبلوغرافية
| العنوان: |
Is insulin the preferred treatment in persons with type 2 diabetes and liver cirrhosis? |
| المؤلفون: |
Yen, Fu-Shun1 (AUTHOR), Lai, Jung-Nien2,3 (AUTHOR), Wei, James Cheng-Chung4,5,6 (AUTHOR), Chiu, Lu-Ting7,8 (AUTHOR), Hsu, Chih-Cheng9,10,11 (AUTHOR), Hou, Ming-Chih12,13 (AUTHOR) mchou@vghtpe.gov.tw, Hwu, Chii-Min12,14 (AUTHOR) chhwu@vghtpe.gov.tw |
| المصدر: |
BMC Gastroenterology. 6/12/2021, Vol. 21 Issue 1, p1-9. 9p. |
| مصطلحات موضوعية: |
*TYPE 2 diabetes, *CIRRHOSIS of the liver, *INSULIN, *PROPORTIONAL hazards models, *MORTALITY, *INSULIN therapy, *LIVER tumors, *RETROSPECTIVE studies, *HYPOGLYCEMIC agents, *DISEASE complications |
| مصطلحات جغرافية: |
TAIWAN |
| مستخلص: |
Background: Insulin is highly recommended for diabetes management in persons with liver cirrhosis. However, few studies have evaluated its long-term effects in these persons. We conducted this study to compare the risks of mortality, liver-related complications, and cardiovascular events in persons with type 2 diabetes mellitus (T2DM) and compensated liver cirrhosis.Methods: From January 1, 2000, to December 31, 2012, we selected 2047 insulin users and 4094 propensity score-matched nonusers from Taiwan's National Health Insurance Research Database. Cox proportional hazard models were used to assess the risks of outcomes.Results: The mean follow-up time was 5.84 years. The death rate during the follow-up period was 5.28 and 4.07 per 100 person-years for insulin users and nonusers, respectively. In insulin users, the hazard ratios and 95% confidence intervals (CIs) of all-cause mortality, hepatocellular carcinoma, decompensated cirrhosis, hepatic failure, major cardiovascular events, and hypoglycemia were 1.31 (1.18-1.45), 1.18 (1.05-1.34), 1.53 (1.35-1.72), 1.26 (1.42-1.86), 1.41 (1.23-1.62), and 3.33 (2.45-4.53), respectively.Conclusions: This retrospective cohort study indicated that among persons with T2DM and compensated liver cirrhosis, insulin users were associated with higher risks of death, liver-related complications, cardiovascular events, and hypoglycemia compared with insulin nonusers. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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