Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes
| العنوان: | Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes |
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| المؤلفون: | Yanfei Wang, Zhiguang Zhou, Qiuqiu Lin, Yanhua Li, Yang Xiao, Binbin He, Yao Yu, Gan Huang, Dewei Ye |
| المصدر: | BMC Endocrine Disorders BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Neutrophils, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Disease, Gastroenterology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, Autoimmune diabetes, Young Adult, 0302 clinical medicine, Risk Factors, Internal medicine, Diabetes mellitus, Medicine, Albuminuria, Humans, Clinical significance, Diabetic Nephropathies, 030212 general & internal medicine, Diabetic kidney disease, Retrospective Studies, Creatinine, Type 1 diabetes, Latent autoimmune diabetes in adults, lcsh:RC648-665, business.industry, Neutrophil, General Medicine, medicine.disease, Prognosis, Diabetes Mellitus, Type 1, chemistry, Absolute neutrophil count, Female, business, Dyslipidemia, Biomarkers, Research Article, Follow-Up Studies |
| الوصف: | Background A growing body of evidence supports neutrophils as having an active role in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remains unknown. This study aimed to investigate the relationship between circulating neutrophils and DKD in autoimmune diabetes. Methods Patients with type 1 diabetes (T1D, n = 226) and latent autoimmune diabetes in adults (LADA, n = 79) were enrolled and stratified according to the urinary albumin to creatinine ratio (ACR). Circulating levels of white blood cells (WBCs), including neutrophils, were measured in a central laboratory, and the neutrophil-to-lymphocyte ratio (NLR) was calculated. The risk factors associated with DKD were analysed by logistic regression. Results In T1D and LADA patients, the peripheral neutrophil counts increased in parallel with DKD advancement. The neutrophil counts in the patients with macroalbuminuria were significantly higher than those in the patients with normoalbuminuria for each type of diabetes. Furthermore, neutrophil counts positively correlated with ACR in T1D. In addition, neutrophils were independently associated with DKD in T1D in the logistic regression analysis, when various well-known risk factors, including age, gender, disease duration, hypertension, dyslipidemia and smoking status, were adjusted. Conclusions Neutrophil counts are closely associated with DKD in patients with autoimmune diabetes, suggesting that neutrophil-mediated inflammation may be involved in the pathogenesis of DKD in patients with autoimmune diabetes. |
| اللغة: | English |
| تدمد: | 1472-6823 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9a1aba7bcef7e7450a62237954e068Test http://europepmc.org/articles/PMC7580021Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ba9a1aba7bcef7e7450a62237954e068 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14726823 |
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