Decursinol from Angelica gigas Nakai enhances endometrial receptivity during implantation
| العنوان: | Decursinol from Angelica gigas Nakai enhances endometrial receptivity during implantation |
|---|---|
| المؤلفون: | Se-In Lee, Jaeku Kang, Young-Hyun Han, Joo Eun Lee, Seong-Eun Kim, Seong-Lan Yu, Seok-Rae Park, Do Kyung Kim |
| المصدر: | BMC Complementary Medicine and Therapies BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adhesion molecule, Cell, Decursinol, Blotting, Western, Integrin, Endometrium, Exosomes, Andrology, 03 medical and health sciences, Paracrine signalling, 0302 clinical medicine, Cell Line, Tumor, Spheroids, Cellular, medicine, Humans, Benzopyrans, Embryo Implantation, Autocrine signalling, Angelica, biology, Molecular Structure, Chemistry, Cell adhesion molecule, Trophoblast, lcsh:Other systems of medicine, lcsh:RZ201-999, biology.organism_classification, In vitro, female genital diseases and pregnancy complications, Implantation, Butyrates, 030104 developmental biology, medicine.anatomical_structure, Angelica gigas, Complementary and alternative medicine, Endometrial receptivity, 030220 oncology & carcinogenesis, Female, Cell Adhesion Molecules, Research Article |
| الوصف: | BackgroundEmbryo implantation is essential for a successful pregnancy, and an elaborate synchronization between the receptive endometrium and trophoblast is required to achieve this implantation. To increase ‘endometrial receptivity’, the endometrium undergoes transformation processes including responses of adhesion molecules and cellular and molecular cell to cell communication. Many natural substances from traditional herbs have been studied to aid in the achievement of successful implantation. In this study, we investigated positive effects on embryonic implantation with decursinol that is a major compound extracted fromAngelica gigasNakai known to be associated with promotion of healthy pregnancy in the traditional Korean herbal medicine.MethodsExpression of cell adhesion molecules after treatment of endometrial epithelial cells by decursinol (40 or 80 μM) was determined using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot analysis. The alteration of endometrial receptivity by decursinol (40 or 80 μM) was identified with the in vitro implantation model between Ishikawa cells and JAr cell spheroids (diameter, 143 ± 16 μm). Exosomes secreted from Ishikawa cells after treatment of 80 μM decursinol or dimethyl sulfoxide (DMSO) as the vehicle were investigated with invasion of JAr cells and attachment of JAr spheroids to Ishikawa cells.ResultsDecursinol significantly (P P ConclusionThese results propose that decursinol could serve as a new and alternative solution for patients who are infertile. |
| اللغة: | English |
| تدمد: | 2662-7671 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f414539ef2ae8546876b78a108708e7Test http://europepmc.org/articles/PMC7076876Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4f414539ef2ae8546876b78a108708e7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26627671 |
|---|