المؤلفون: Delshad Aghdam, Saeideh, Siassi, Fereydoun, Nasli Esfahani, Ensieh, Qorbani, Mostafa, Rajab, Asadollah, Sajjadpour, Zahra, Bashiri, Anahita, Aghayan, Maryam, Sotoudeh, Gity

المصدر: BMC Cardiovascular Disorders; 6/12/2021, Vol. 21 Issue 1, p1-11, 11p

مصطلحات موضوعية: TYPE 1 diabetes, LDL cholesterol, CARDIOVASCULAR diseases risk factors, HDL cholesterol, CARDIOVASCULAR diseases, BLOOD lipids, TYPE 2 diabetes

مستخلص: Background: Dietary phytochemical index (DPI) is useful and inexpensive method to identify the role of phytochemicals on cardiovascular disease (CVD) risk factors. This study aimed to assess the relationship between DPI and CVD risk factors in patients with type1 diabetes mellitus.Methods: A total of 261 participants aged 18-35 years with T1DM were enrolled in this cross-sectional study to assess the relationship between DPI and CVD risk factors. Anthropometric measurements, blood lipids, glucose, and antioxidant level were measured. Food intakes were determined using a food frequency questionnaire to calculate DPI. Logistic regression was used.Results: The mean age of participants was 25 years. After adjustment for potential confounders, participants in the highest tertile of DPI had 88 % lower chance of hyperglycemia (P for trend = 0.020), 81 % lower chance of low high-density lipoprotein cholesterol (HDL-C) (P for trend = 0.030) and 98 % lower chance of high low-density lipoprotein cholesterol to HDL-C ratio (P for tend = 0.040). There were no relationships between DPI and other CVD risk factors.Conclusions: Although higher intake of phytochemical-rich foods had a beneficial effect on some risk factors of CVD, more studies more studies are warranted to corroborate the present findings. [ABSTRACT FROM AUTHOR]

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المؤلفون: Fei Yan, Qiang Huo, Weimin Zhang, Tingting Wu, Daniyaer Dilimulati, Lin Shi

المصدر: BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-8 (2022)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, Wnt/β-catenin, miR-138-5p, Research, RUNX2, Calcinosis, Cell Differentiation, Core Binding Factor Alpha 1 Subunit, Aortic Valve Stenosis, MicroRNAs, Gene Expression Regulation, Calcific aortic valve disease (CAVD), Osteogenesis, Aortic Valve, Osteogenic differentiation, RC666-701, Humans, Diseases of the circulatory (Cardiovascular) system, Female, Aortic valve interstitial cells (AVICs), Cardiology and Cardiovascular Medicine, Wnt Signaling Pathway, Cells, Cultured, beta Catenin

الوصف: Background Human aortic valve interstitial cells (hAVICs) are a key factor in the pathogenesis of calcific aortic valve disease (CAVD). This research examines the role and mechanism of microRNA miR-138-5p in osteogenic differentiation of hAVICs. Methods RT-qPCR analysis was applied for detecting miR-138-5p and RUNX2 expression in valve tissues of CAVD patients and controls. On completion of induction of osteogenic differentiation of hAVICs, and after overexpression or interference of miR-138-5p expression, the condition of osteogenic differentiation and calcification of hAVICs was confirmed using alkaline phosphatase staining and alizarin red staining. Subsequently, western blot was utilized to detect the expression of osteogenesis-related proteins OPN and ALP, and Wnt/β-catenin signaling pathway-related proteins. Finally, the relationship between miR-138-5p and RUNX2 was validated by dual-luciferase reporter assay and Pearson’s correlation test. Results Down-regulation of miR-138-5p was found in CAVD patients and during osteogenic differentiation of hAVICs. Overexpression of miR-138-5p contribute to the inhibition of osteoblast differentiation and calcium deposition in hAVICs, and of ALP and OPN protein expression. RUNX2 was a target gene of miR-138-5p, and it was negatively correlated with miR-138-5p in CAVD. Additionally, overexpression of RUNX2 could reverse the inhibitory effect of miR-138-5p on osteogenic differentiation of hAVICs. Conclusion miR-138-5p can act as a positive regulator of osteogenic differentiation in CAVD patients to involve in inhibiting valve calcification, which is achieved through RUNX2 and Wnt/β-catenin signaling pathway.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bd5933c6f99a56b73ca18104f8455aTest
https://doaj.org/article/f0866dfb20a540fcaad44cebd50df8f1Test

المؤلفون: Li Xu, Xinchun Yang, Peijia Wang, Jie Wei, Yuxia Pan, Yuanfeng Gao, Mulei Chen, Wenkai Liao

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Acute myocardial infarction, Risk Assessment, Thrombospondin 1, Young Adult, Predictive Value of Tests, Risk Factors, Internal medicine, Tachycardia, Supraventricular, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Myocardial infarction, cardiovascular diseases, Atrial tachycardia, Aged, Angiology, business.industry, Atrial arrhythmias, Research, Percutaneous coronary intervention, Atrial fibrillation, Middle Aged, medicine.disease, Up-Regulation, Cardiac surgery, Atrial Flutter, RC666-701, Cardiology, cardiovascular system, Female, Atrial Premature Complexes, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Atrial remodeling, Biomarkers, Atrial flutter, Thrombospondin-1

الوصف: Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p p p p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion TSP-1 is a potential novel indicator of atrial arrhythmias during AMI. Graphical abstract

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c276ecfb1cc2a5c667b562f21ad7d3bTest
https://doaj.org/article/9714c38885a046f6b9cf5c1a816f4ccfTest

المؤلفون: Zhexun Lian, Mingqiang Fu, Jingmin Zhou, Xiaotong Cui, Junbo Ge, Mengying Xu, Fuhai Li, Hui Xin

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Diastole, Heart failure, Patient Readmission, Risk Assessment, Ventricular Function, Left, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Prospective Studies, Interventricular septum, Prospective cohort study, Soluble suppression of tumorigenicity 2, Aged, Cardiac remodeling, Ejection fraction, Ventricular Remodeling, Proportional hazards model, business.industry, Hazard ratio, Stroke Volume, Middle Aged, medicine.disease, Heart failure with reduced ejection fraction, Interleukin-1 Receptor-Like 1 Protein, Magnetic Resonance Imaging, Progression-Free Survival, Cardiac surgery, medicine.anatomical_structure, Echocardiography, RC666-701, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Left ventricular mass index, Research Article, Heart Failure, Systolic

الوصف: Background Inflammation is one of the principal triggering mechanisms for left ventricular fibrosis and remodeling in heart failure, leading to adverse clinical outcomes. Soluble suppression of tumorigenicity 2 (sST2), a member of the interleukin-1 receptor family, is assumed to play a significant role in the fibrotic response to inflammation. Left ventricular mass index (LVMI) is a parameter of the prefibrotic inflammatory phase of heart failure preceding remodeling. The present study aimed to investigate the prognostic value of the sST2/LVMI ratio in heart failure with reduced ejection fraction. Methods This was a prospective cohort study. A total of 45 consecutive patients with heart failure with reduced ejection fraction, treated between September 2015 and December 2016, were enrolled. The sST2/LVMI ratio was measured at baseline. The primary endpoint was a composite of cardiovascular mortality and readmission for heart failure. The prognostic impact of the sST2/LVMI ratio was evaluated using a multivariable Cox proportional hazards regression model. Results Forty-five patients were enrolled in this study. Their average age was 48 ± 14 years, and approximately 20% of them were men. Patients were followed for 9 months, during which the primary outcome occurred in 15 patients. Kaplan–Meier analysis showed that patients with a high sST2/LVMI ratio (≥ 0.39) had shorter event-free survival than those with intermediate (between 0.39 and 0.24) and low ratios (P = 0.022). The fully adjusted multivariable Cox regression analysis showed that the sST2/LVMI ratio was positively associated with the composite outcome in patients with heart failure with reduced ejection fraction after adjusting for confounders (hazard ratio 1.64, 95% confidence interval 1.06 to 2.54). By subgroup analysis, a stronger association was found with age between 40 and 55 years, systolic blood pressure Conclusion In patients with heart failure with reduced ejection fraction, the relationship between the sST2/LVMI ratio and the composite outcome was linear. A higher baseline ratio of sST2/LVMI was associated with an increased risk of cardiovascular mortality and heart failure rehospitalization in the short-term follow-up.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acf5350a95acef7443b8770df6f59daTest
https://doaj.org/article/8689d0f3811f40829023f669a2059f3dTest

المؤلفون: Laurits Juhl Heinsen, Gokulan Pararajasingam, Johanna Larsson, Thomas Rueskov Andersen, Rasmus Møgelvang, Jørgen Hangaard, Søren Auscher, Kenneth Egstrup, Brian Bridal Løgstrup

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021)
Pararajasingam, G, Heinsen, L J, Larsson, J, Andersen, T R, Løgstrup, B B, Auscher, S, Hangaard, J, Møgelvang, R & Egstrup, K 2021, ' Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus : a cross-sectional study ', BMC Cardiovascular Disorders, vol. 21, 269 . https://doi.org/10.1186/s12872-021-02063-wTest
BMC Cardiovascular Disorders

مصطلحات موضوعية: Male, Global longitudinal strain, Computed Tomography Angiography, Diabetic Cardiomyopathies, Denmark, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Ventricular Function, Left, Coronary artery disease, Ventricular Dysfunction, Left, 0302 clinical medicine, Diabetes mellitus, Risk Factors, Outpatient clinic, 030212 general & internal medicine, Middle Aged, Prognosis, Echocardiography, Doppler, Cardiac surgery, Asymptomatic, Plaque burden, Echocardiography, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Research Article, Adult, medicine.medical_specialty, Microvascular complications, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Aged, Angiology, Type 1 diabetes, business.industry, Microcirculation, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 2, RC666-701, Asymptomatic Diseases, business, Body mass index, Diabetic Angiopathies

الوصف: Background Reduced left ventricular function, assessed by global longitudinal strain (GLS), is sometimes observed in asymptomatic patients with diabetes mellitus (DM) and is often present in patients with diabetes-related microvascular complications. Our aim was to assess the association between microvascular complications, coronary artery plaque burden (PB) and GLS in asymptomatic patients with DM and non-obstructive coronary artery disease (CAD). Methods This cross-sectional study included patients with DM without any history, symptoms or objective evidence of obstructive CAD. All patients were identified in the outpatient Clinic of Endocrinology at Odense University Hospital Svendborg. An echocardiography and a coronary computed tomography angiography were performed to assess GLS and the degree of CAD, respectively. A coronary artery stenosis Results Two hundred and twenty-two patients were included, of whom 172 (77%) had type 2 DM and 50 (23%) had type 1 diabetes. One hundred and eleven (50%) patients had microvascular complications. GLS decreased as the burden of microvascular complications increased (P-trend = 0.01): no microvascular complications, GLS (− 16.4 ± 2.5%), 1 microvascular complication (− 16.0 ± 2.5%) and 2–3 microvascular complications (− 14.9 ± 2.8%). The reduction in GLS remained significant after multivariable adjustment (β 0.50 [95% CI 0.11–0.88], p = 0.01). BMI (β 0.12 [95% CI 0.05–0.19]) and MAP (β 0.05 [95% CI 0.01–0.08]) were associated with reduced GLS. In addition, an increased number of microvascular complications was associated with increased PB (β 2.97 [95% CI 0.42–5.51], p = 0.02) in a univariable linear regression model, whereas there was no significant association between PB and GLS. Conclusions The burden of microvascular complications was associated with reduced GLS independent of other cardiovascular risk factors in asymptomatic patients with DM and non-obstructive CAD. In addition, the burden of microvascular complications was associated with increasing PB, whereas PB was not associated with GLS.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7354a22018e22dd02e46833531a7fd88Test
https://doaj.org/article/b481711d27914233843a352a05a27001Test

المؤلفون: Jingze Zhang, Mei Wu, Long Liu, Haiming Xu

المصدر: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-6 (2021)

مصطلحات موضوعية: Adult, Male, Caveolin 1, CAD, Computational biology, Coronary Artery Disease, Coronary artery disease, Transcription (biology), microRNA, Weighted gene co-expression network analysis, Databases, Genetic, Diseases of the circulatory (Cardiovascular) system, Medicine, Humans, Differentially expressed mRNA, Gene Regulatory Networks, RNA, Messenger, Gene, Genetic Association Studies, Heat-Shock Proteins, Aged, Oligonucleotide Array Sequence Analysis, Messenger RNA, business.industry, Gene Expression Profiling, Middle Aged, medicine.disease, Exact test, MicroRNAs, medicine.anatomical_structure, RC666-701, Case-Control Studies, Differentially expressed miRNA, Female, Cardiology and Cardiovascular Medicine, business, Transcriptome, Artery, Research Article, Transcription Factors

الوصف: Background To illustrate the mechanism of miRNA and mRNA in coronary artery diseasen (CAD), differentially expressed microRNAs (DEmiRNAs) and genes (DEGs) were analyzed. Methods The mRNA transcription profiles of GSE20680 (including 87 blood samples of CAD and 52 blood samples of control), GSE20681 (including 99 blood samples of CAD and 99 blood samples of control) and GSE12288 (including 110 blood samples of CAD and 112 blood samples of control) and the miRNA transcription profiles of GSE59421 (including 33 blood samples of CAD and 37 blood samples of control), GSE49823 (including 12 blood samples of CAD and 12 blood samples of control) and GSE28858 (including 13 blood samples of CAD and 13 blood samples of control) were downloaded from Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geoTest/). Then, the homogenous expressed mRNAs and miRNAs across the three mRNA transcription profiles and three miRNA transcription profiles were screened using the Fishers exact test in MetaDE. ES package. The weighted gene co-expression network analysis (WGCNA) was used to analyze gene modules. Additionally, the integrated miRNAs–targets regulatory network using the DEmiRNA and their targets was constructed using Cytoscape. Results A total of 1201 homogenously statistically significant DEGs were identified including 879 up-regulated and 322 down-regulated DEGs, while a total of 47 homogenously statistically significant DEmiRNAs including 37 up-regulated and 10 down-regulated DEmiRNAs in CAD compared with the controls across the three mRNA transcription profiles and the three miRNA transcription profiles. A total of 5067 genes were clustered into 9 modules in the training dataset, among which, 8 modules were validated. In the miRNAs-targets network, there existed 267 interaction relationships among 5 miRNAs (hsa-miR-361-5p, hsa-miR-139-5p, hsa-miR-146b-5p, hsa-miR-502-5p and hsa-miR-501-5p) and 213 targets. CAV1 could be the target of hsa-miR-361-5 while HSF2 was the target of both hsa-miR-361-5p and hsa-miR-146b-5p. CAV1 was significantly enriched in the GO term of regulation of cell proliferation. Conclusion hsa-miR-361-5p, has-miR-146b-5p, CAV1 and HSF2 could play an important role in CAD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab1463a7579d5d7a7cff0f79c82c7dfTest
http://europepmc.org/articles/PMC8447760Test

المؤلفون: Harm W.J. van Marwijk, Isaac Ssinabulya, Hilde Bastiaens, Rawlance Ndejjo, Geofrey Musinguzi, Rhoda K. Wanyenze

المصدر: BMC cardiovascular disorders
BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Social Determinants of Health, Psychological intervention, Context (language use), Disease cluster, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Epidemiology, Diabetes Mellitus, medicine, Prevalence, Cluster Analysis, Humans, Uganda, Obesity, 030212 general & internal medicine, Risk factor, Life Style, Small-Area Analysis, Cardiovascular risk factors, Aged, 2. Zero hunger, Descriptive statistics, Sub-Saharan Africa, business.industry, 030503 health policy & services, 1. No poverty, Middle Aged, medicine.disease, 3. Good health, Cardiovascular Diseases, Heart Disease Risk Factors, lcsh:RC666-701, Hypertension, Female, Human medicine, 0305 other medical science, Cardiology and Cardiovascular Medicine, business, Research Article

الوصف: Background Sub-Saharan Africa (SSA) is experiencing an increasing burden of Cardiovascular Diseases (CVDs). Modifiable risk factors including hypertension, diabetes, obesity, central obesity, sedentary behaviours, smoking, poor diet (characterised by inadequate vegetable and fruit consumption), and psychosocial stress are attributable to the growing burden of CVDs. Small geographical area mapping and analysis of these risk factors for CVD is lacking in most of sub-Saharan Africa and yet such data has the potential to inform monitoring and exploration of patterns of morbidity, health-care use, and mortality, as well as the epidemiology of risk factors. In the current study, we map and describe the distribution of the CVD risk factors in 20 parishes in two neighbouring districts in Uganda. Methods A baseline survey benchmarking a type-2 hybrid stepped wedge cluster randomised trial design was conducted in December 2018 and January 2019. A sample of 4372 adults aged 25–70 years was drawn from 3689 randomly selected households across 80 villages in 20 parishes in Mukono and Buikwe districts in Uganda. Descriptive statistics and generalized linear modelling controlled for clustering were conducted for this analysis in Stata 13.0, and a visual map showing risk factor distribution developed in QGIS. Results Mapping the prevalence of selected CVD risk factors indicated substantial gender and small area geographic heterogeneity which was masked on aggregate analysis. Patterns and clustering were observed for hypertension, physical inactivity, smoking, alcohol consumption and risk factor combination. Prevalence of unhealthy diet was very high across all parishes with no significant observable differences across areas. Conclusion Modifiable cardiovascular risk factors are common in this low-income context. Moreover, across small area geographic setting, it appears significant differences in distribution of risk factors exist. These differences suggest that underlying drivers such as sociocultural, environmental and economic determinants may be promoting or inhibiting the observed risk factor prevalences which should be further explored. In addition, the differences emphasize the value of small geographical area mapping and analysis to inform more targeted risk reduction interventions.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b540c7dc6a0b93310f46135c90de1060Test
https://hdl.handle.net/10067/1697870151162165141Test

المؤلفون: Yi Sun, Qiyu Lu, Yuyin Duan, Bin Li, Guimin Zhang, Songhua Yu, Jianming Xia

المصدر: BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Genetic Markers, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Heart disease, medicine.medical_treatment, Interleukin-1beta, 030204 cardiovascular system & hematology, Interleukin 1, 03 medical and health sciences, 0302 clinical medicine, Mitral valve stenosis, Mitral valve, medicine, Humans, Mitral valve prolapse, Circulating MicroRNA, Heart valve, Rheumatic heart disease, Aged, miRNA, Receptors, Interleukin-1 Type I, Inflammation, Mitral Valve Prolapse, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Gene Expression Profiling, valvular heart disease, Mitral valve replacement, Mitral Valve Insufficiency, Middle Aged, medicine.disease, Valvular heart disease, MicroRNAs, HEK293 Cells, 030104 developmental biology, medicine.anatomical_structure, lcsh:RC666-701, Case-Control Studies, Mitral Valve, Rheumatic fever, Female, Cardiology and Cardiovascular Medicine, business, Signal Transduction, Research Article

الوصف: Background Valvular heart disease is a leading cause of cardiovascular mortality, especially in China. More than a half of valvular heart diseases are caused by acute rheumatic fever. microRNA is involved in many physiological and pathological processes. However, the miRNA profile of the rheumatic valvular heart disease is unknown. This research is to discuss microRNAs and their target gene pathways involved in rheumatic heart valve disease. Methods Serum miRNA from one healthy individual and four rheumatic heart disease patients were sequenced. Specific differentially expressed miRNAs were quantified by Q-PCR in 40 patients, with 20 low-to-moderate rheumatic mitral valve stenosis patients and 20 severe mitral valve stenosis patients. The target relationship between certain miRNA and predicted target genes were analysis by Luciferase reporter assay. The IL-1β and IL1R1 expression levels were analyzed by immunohistochemistry and western blot in the mitral valve from surgery of mitral valve replacement. Results The results showed that 13 and 91 miRNAs were commonly upregulated or downregulated in all four patients. Nine miRNAs, 1 upregulated and 8 downregulated, that had a similar fold change in all 4 patients were selected for quantitative PCR verification. The results showed similar results from miRNA sequencing. Within these 9 tested miRNAs, hsa-miR-205-3p and hsa-miR-3909 showed a low degree of dispersion between the members of each group. Hsa miR-205-3p and hsa-miR-3909 were predicted to target the 3’UTR of IL-1β and IL1R1 respectively. This was verified by luciferase reporter assays. Immunohistochemistry and Western blot results showed that the mitral valve from rheumatic valve heart disease showed higher levels of IL- 1β and IL1R1 expression compared with congenital heart valve disease. This suggested a difference between rheumatic heart valve disease and other types of heart valve diseases, with more inflammatory responses in the former. Conclusion In the present study, by next generation sequencing of miRNAs, it was revealed that interleukin 1β and interleukin 1 receptor 1 was involved in rheumatic heart diseases. And this is useful for diagnosis and understanding of mechanism of rheumatic heart disease. Electronic supplementary material The online version of this article (10.1186/s12872-018-0788-2) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86232bb6809ca1dcbf106e8d5173d521Test
http://link.springer.com/article/10.1186/s12872-018-0788-2Test

المؤلفون: Marília B. Gomes, Eduardo Tibiriçá, Diogo Van Bavel, Roger de Moraes

المصدر: BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, Nitroprusside, medicine.medical_specialty, Pathology, Endothelium, Intravital Microscopy, Vasodilator Agents, 030209 endocrinology & metabolism, Hyperemia, 030204 cardiovascular system & hematology, Microvascular rarefaction, Microcirculation, Exercise training, Fingers, 03 medical and health sciences, Laser Doppler flowmetry, 0302 clinical medicine, Internal medicine, Laser-Doppler Flowmetry, Medicine, Aerobic exercise, Humans, Endothelial dysfunction, Reactive hyperemia, Skin, Microscopy, Video, business.industry, Microvascular Density, Iontophoresis, medicine.disease, Acetylcholine, Capillaries, Exercise Therapy, Vasodilation, Forearm, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Treatment Outcome, Regional Blood Flow, Cardiology, Microvascular Rarefaction, Female, Endothelium, Vascular, business, Cardiology and Cardiovascular Medicine, Intravital microscopy, Research Article

الوصف: Background The aim of the present study was to evaluate changes in microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training. Methods This study included 22 (34 ± 7 years) consecutive outpatients with T1D and disease duration > 6 years. We used intravital video-microscopy to measure basal skin capillary density and capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers. Endothelium-dependent and -independent vasodilation of the skin microcirculation was evaluated in the forearm with a laser Doppler flow monitoring (LDF) system in combination with acetylcholine and sodium nitroprusside iontophoresis, PORH and local thermal hyperemia. Results The basal mean capillary density (MCD) after exercise training was significantly higher than before exercise (134 ± 25 vs. 119 ± 19 capillaries/mm2, respectively; P = 0.0013). MCD during PORH was also higher after exercise (140 ± 26 vs. 121 ± 24 capillaries/mm2, respectively; P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bbea1111df2c51b92e3d68ccb111e7Test
http://europepmc.org/articles/PMC4728937Test

المؤلفون: Bledar Daka, Per-Anders Jansson, Charlotte A Larsson, Ulf Lindblad, Lennart Råstam, Josefin Olausson, Margareta Hellgren

المصدر: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders; 15(1), no 146 (2015)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Coronary Disease, Disease, Kaplan-Meier Estimate, Risk Assessment, Skaraborg project, Sex Factors, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Cardiac and Cardiovascular Systems, Longitudinal Studies, Prospective Studies, Prospective study, Prospective cohort study, Angiology, Aged, Proportional Hazards Models, Sweden, Framingham Risk Score, Endothelin-1, business.industry, Proportional hazards model, Incidence, Middle Aged, Prognosis, Endothelin 1, Cardiac surgery, Up-Regulation, Coronary heart disease, Cohort, Multivariate Analysis, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Research Article

الوصف: Background The vasoconstricting peptide endothelin-1 has been proposed to be a marker of cardiovascular disease. Our aim was to investigate whether circulating endothelin-1 levels predict coronary heart disease (CHD) in Sweden. Methods In 2002–2005, 2816 adult participants (30–74 years) were randomly selected from two municipalities in south-western Sweden. Cardiovascular risk factors and endothelin-1 levels were assessed at baseline, and incident CHD was followed-up in all participants through 2011. After exclusion of 50 participants due to known CHD at baseline and 21 participants because of unsuccessful analysis of endothelin-1, 2745 participants were included in the study. In total, 72 CHD events (52 in men and 20 in women) were registered during the follow-up time. Results We showed that baseline circulating endothelin-1 levels were higher in women with incident CHD than in women without CHD (3.2 pg/ml, SE: 0.36 vs 2.4 pg/ml, SE: 0.03, p = 0.003) whereas this difference was not observed in men (2.3 pg/ml, SE: 0.16 vs 2.3 pg/ml, SE: 0.04, p = 0.828). An age-adjusted Cox proportional regression analysis showed an enhanced risk of CHD with increasing baseline endothelin-1 levels in women (hazard ratio (HR) = 1.51, 95 % CI = 1.1–2.1, p = 0.015) but not in men (HR = 0.98, 95 % CI = 0.8–1.2, p = 0.854). Furthermore, the predictive value of endothelin-1 for incident CHD in women was still significant after adjustments for age, HOMA-IR, apolipoprotein (apo)B/apoA1 and smoking (HR = 1.53, CI = 1.1–1.2, p = 0.024). Conclusion Circulating endothelin-1 levels may predict CHD in women.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f698bfcc453bc110094f904d93a11eTest
http://europepmc.org/articles/PMC4647275Test