Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus: a cross-sectional study
| العنوان: | Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus: a cross-sectional study |
|---|---|
| المؤلفون: | Laurits Juhl Heinsen, Gokulan Pararajasingam, Johanna Larsson, Thomas Rueskov Andersen, Rasmus Møgelvang, Jørgen Hangaard, Søren Auscher, Kenneth Egstrup, Brian Bridal Løgstrup |
| المصدر: | BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021) Pararajasingam, G, Heinsen, L J, Larsson, J, Andersen, T R, Løgstrup, B B, Auscher, S, Hangaard, J, Møgelvang, R & Egstrup, K 2021, ' Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus : a cross-sectional study ', BMC Cardiovascular Disorders, vol. 21, 269 . https://doi.org/10.1186/s12872-021-02063-wTest BMC Cardiovascular Disorders |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Global longitudinal strain, Computed Tomography Angiography, Diabetic Cardiomyopathies, Denmark, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Ventricular Function, Left, Coronary artery disease, Ventricular Dysfunction, Left, 0302 clinical medicine, Diabetes mellitus, Risk Factors, Outpatient clinic, 030212 general & internal medicine, Middle Aged, Prognosis, Echocardiography, Doppler, Cardiac surgery, Asymptomatic, Plaque burden, Echocardiography, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Research Article, Adult, medicine.medical_specialty, Microvascular complications, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Aged, Angiology, Type 1 diabetes, business.industry, Microcirculation, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 2, RC666-701, Asymptomatic Diseases, business, Body mass index, Diabetic Angiopathies |
| الوصف: | Background Reduced left ventricular function, assessed by global longitudinal strain (GLS), is sometimes observed in asymptomatic patients with diabetes mellitus (DM) and is often present in patients with diabetes-related microvascular complications. Our aim was to assess the association between microvascular complications, coronary artery plaque burden (PB) and GLS in asymptomatic patients with DM and non-obstructive coronary artery disease (CAD). Methods This cross-sectional study included patients with DM without any history, symptoms or objective evidence of obstructive CAD. All patients were identified in the outpatient Clinic of Endocrinology at Odense University Hospital Svendborg. An echocardiography and a coronary computed tomography angiography were performed to assess GLS and the degree of CAD, respectively. A coronary artery stenosis Results Two hundred and twenty-two patients were included, of whom 172 (77%) had type 2 DM and 50 (23%) had type 1 diabetes. One hundred and eleven (50%) patients had microvascular complications. GLS decreased as the burden of microvascular complications increased (P-trend = 0.01): no microvascular complications, GLS (− 16.4 ± 2.5%), 1 microvascular complication (− 16.0 ± 2.5%) and 2–3 microvascular complications (− 14.9 ± 2.8%). The reduction in GLS remained significant after multivariable adjustment (β 0.50 [95% CI 0.11–0.88], p = 0.01). BMI (β 0.12 [95% CI 0.05–0.19]) and MAP (β 0.05 [95% CI 0.01–0.08]) were associated with reduced GLS. In addition, an increased number of microvascular complications was associated with increased PB (β 2.97 [95% CI 0.42–5.51], p = 0.02) in a univariable linear regression model, whereas there was no significant association between PB and GLS. Conclusions The burden of microvascular complications was associated with reduced GLS independent of other cardiovascular risk factors in asymptomatic patients with DM and non-obstructive CAD. In addition, the burden of microvascular complications was associated with increasing PB, whereas PB was not associated with GLS. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2261 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7354a22018e22dd02e46833531a7fd88Test https://doaj.org/article/b481711d27914233843a352a05a27001Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7354a22018e22dd02e46833531a7fd88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712261 |
|---|