المؤلفون: Laurits Juhl Heinsen, Gokulan Pararajasingam, Johanna Larsson, Thomas Rueskov Andersen, Rasmus Møgelvang, Jørgen Hangaard, Søren Auscher, Kenneth Egstrup, Brian Bridal Løgstrup

المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021)
Pararajasingam, G, Heinsen, L J, Larsson, J, Andersen, T R, Løgstrup, B B, Auscher, S, Hangaard, J, Møgelvang, R & Egstrup, K 2021, ' Diabetic microvascular complications are associated with reduced global longitudinal strain independent of atherosclerotic coronary artery disease in asymptomatic patients with diabetes mellitus : a cross-sectional study ', BMC Cardiovascular Disorders, vol. 21, 269 . https://doi.org/10.1186/s12872-021-02063-wTest
BMC Cardiovascular Disorders

مصطلحات موضوعية: Male, Global longitudinal strain, Computed Tomography Angiography, Diabetic Cardiomyopathies, Denmark, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Ventricular Function, Left, Coronary artery disease, Ventricular Dysfunction, Left, 0302 clinical medicine, Diabetes mellitus, Risk Factors, Outpatient clinic, 030212 general & internal medicine, Middle Aged, Prognosis, Echocardiography, Doppler, Cardiac surgery, Asymptomatic, Plaque burden, Echocardiography, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Research Article, Adult, medicine.medical_specialty, Microvascular complications, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Aged, Angiology, Type 1 diabetes, business.industry, Microcirculation, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 2, RC666-701, Asymptomatic Diseases, business, Body mass index, Diabetic Angiopathies

الوصف: Background Reduced left ventricular function, assessed by global longitudinal strain (GLS), is sometimes observed in asymptomatic patients with diabetes mellitus (DM) and is often present in patients with diabetes-related microvascular complications. Our aim was to assess the association between microvascular complications, coronary artery plaque burden (PB) and GLS in asymptomatic patients with DM and non-obstructive coronary artery disease (CAD). Methods This cross-sectional study included patients with DM without any history, symptoms or objective evidence of obstructive CAD. All patients were identified in the outpatient Clinic of Endocrinology at Odense University Hospital Svendborg. An echocardiography and a coronary computed tomography angiography were performed to assess GLS and the degree of CAD, respectively. A coronary artery stenosis Results Two hundred and twenty-two patients were included, of whom 172 (77%) had type 2 DM and 50 (23%) had type 1 diabetes. One hundred and eleven (50%) patients had microvascular complications. GLS decreased as the burden of microvascular complications increased (P-trend = 0.01): no microvascular complications, GLS (− 16.4 ± 2.5%), 1 microvascular complication (− 16.0 ± 2.5%) and 2–3 microvascular complications (− 14.9 ± 2.8%). The reduction in GLS remained significant after multivariable adjustment (β 0.50 [95% CI 0.11–0.88], p = 0.01). BMI (β 0.12 [95% CI 0.05–0.19]) and MAP (β 0.05 [95% CI 0.01–0.08]) were associated with reduced GLS. In addition, an increased number of microvascular complications was associated with increased PB (β 2.97 [95% CI 0.42–5.51], p = 0.02) in a univariable linear regression model, whereas there was no significant association between PB and GLS. Conclusions The burden of microvascular complications was associated with reduced GLS independent of other cardiovascular risk factors in asymptomatic patients with DM and non-obstructive CAD. In addition, the burden of microvascular complications was associated with increasing PB, whereas PB was not associated with GLS.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7354a22018e22dd02e46833531a7fd88Test
https://doaj.org/article/b481711d27914233843a352a05a27001Test

المؤلفون: Harm W.J. van Marwijk, Isaac Ssinabulya, Hilde Bastiaens, Rawlance Ndejjo, Geofrey Musinguzi, Rhoda K. Wanyenze

المصدر: BMC cardiovascular disorders
BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Social Determinants of Health, Psychological intervention, Context (language use), Disease cluster, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Epidemiology, Diabetes Mellitus, medicine, Prevalence, Cluster Analysis, Humans, Uganda, Obesity, 030212 general & internal medicine, Risk factor, Life Style, Small-Area Analysis, Cardiovascular risk factors, Aged, 2. Zero hunger, Descriptive statistics, Sub-Saharan Africa, business.industry, 030503 health policy & services, 1. No poverty, Middle Aged, medicine.disease, 3. Good health, Cardiovascular Diseases, Heart Disease Risk Factors, lcsh:RC666-701, Hypertension, Female, Human medicine, 0305 other medical science, Cardiology and Cardiovascular Medicine, business, Research Article

الوصف: Background Sub-Saharan Africa (SSA) is experiencing an increasing burden of Cardiovascular Diseases (CVDs). Modifiable risk factors including hypertension, diabetes, obesity, central obesity, sedentary behaviours, smoking, poor diet (characterised by inadequate vegetable and fruit consumption), and psychosocial stress are attributable to the growing burden of CVDs. Small geographical area mapping and analysis of these risk factors for CVD is lacking in most of sub-Saharan Africa and yet such data has the potential to inform monitoring and exploration of patterns of morbidity, health-care use, and mortality, as well as the epidemiology of risk factors. In the current study, we map and describe the distribution of the CVD risk factors in 20 parishes in two neighbouring districts in Uganda. Methods A baseline survey benchmarking a type-2 hybrid stepped wedge cluster randomised trial design was conducted in December 2018 and January 2019. A sample of 4372 adults aged 25–70 years was drawn from 3689 randomly selected households across 80 villages in 20 parishes in Mukono and Buikwe districts in Uganda. Descriptive statistics and generalized linear modelling controlled for clustering were conducted for this analysis in Stata 13.0, and a visual map showing risk factor distribution developed in QGIS. Results Mapping the prevalence of selected CVD risk factors indicated substantial gender and small area geographic heterogeneity which was masked on aggregate analysis. Patterns and clustering were observed for hypertension, physical inactivity, smoking, alcohol consumption and risk factor combination. Prevalence of unhealthy diet was very high across all parishes with no significant observable differences across areas. Conclusion Modifiable cardiovascular risk factors are common in this low-income context. Moreover, across small area geographic setting, it appears significant differences in distribution of risk factors exist. These differences suggest that underlying drivers such as sociocultural, environmental and economic determinants may be promoting or inhibiting the observed risk factor prevalences which should be further explored. In addition, the differences emphasize the value of small geographical area mapping and analysis to inform more targeted risk reduction interventions.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b540c7dc6a0b93310f46135c90de1060Test
https://hdl.handle.net/10067/1697870151162165141Test

المؤلفون: Yi Sun, Qiyu Lu, Yuyin Duan, Bin Li, Guimin Zhang, Songhua Yu, Jianming Xia

المصدر: BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Genetic Markers, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Heart disease, medicine.medical_treatment, Interleukin-1beta, 030204 cardiovascular system & hematology, Interleukin 1, 03 medical and health sciences, 0302 clinical medicine, Mitral valve stenosis, Mitral valve, medicine, Humans, Mitral valve prolapse, Circulating MicroRNA, Heart valve, Rheumatic heart disease, Aged, miRNA, Receptors, Interleukin-1 Type I, Inflammation, Mitral Valve Prolapse, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Gene Expression Profiling, valvular heart disease, Mitral valve replacement, Mitral Valve Insufficiency, Middle Aged, medicine.disease, Valvular heart disease, MicroRNAs, HEK293 Cells, 030104 developmental biology, medicine.anatomical_structure, lcsh:RC666-701, Case-Control Studies, Mitral Valve, Rheumatic fever, Female, Cardiology and Cardiovascular Medicine, business, Signal Transduction, Research Article

الوصف: Background Valvular heart disease is a leading cause of cardiovascular mortality, especially in China. More than a half of valvular heart diseases are caused by acute rheumatic fever. microRNA is involved in many physiological and pathological processes. However, the miRNA profile of the rheumatic valvular heart disease is unknown. This research is to discuss microRNAs and their target gene pathways involved in rheumatic heart valve disease. Methods Serum miRNA from one healthy individual and four rheumatic heart disease patients were sequenced. Specific differentially expressed miRNAs were quantified by Q-PCR in 40 patients, with 20 low-to-moderate rheumatic mitral valve stenosis patients and 20 severe mitral valve stenosis patients. The target relationship between certain miRNA and predicted target genes were analysis by Luciferase reporter assay. The IL-1β and IL1R1 expression levels were analyzed by immunohistochemistry and western blot in the mitral valve from surgery of mitral valve replacement. Results The results showed that 13 and 91 miRNAs were commonly upregulated or downregulated in all four patients. Nine miRNAs, 1 upregulated and 8 downregulated, that had a similar fold change in all 4 patients were selected for quantitative PCR verification. The results showed similar results from miRNA sequencing. Within these 9 tested miRNAs, hsa-miR-205-3p and hsa-miR-3909 showed a low degree of dispersion between the members of each group. Hsa miR-205-3p and hsa-miR-3909 were predicted to target the 3’UTR of IL-1β and IL1R1 respectively. This was verified by luciferase reporter assays. Immunohistochemistry and Western blot results showed that the mitral valve from rheumatic valve heart disease showed higher levels of IL- 1β and IL1R1 expression compared with congenital heart valve disease. This suggested a difference between rheumatic heart valve disease and other types of heart valve diseases, with more inflammatory responses in the former. Conclusion In the present study, by next generation sequencing of miRNAs, it was revealed that interleukin 1β and interleukin 1 receptor 1 was involved in rheumatic heart diseases. And this is useful for diagnosis and understanding of mechanism of rheumatic heart disease. Electronic supplementary material The online version of this article (10.1186/s12872-018-0788-2) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86232bb6809ca1dcbf106e8d5173d521Test
http://link.springer.com/article/10.1186/s12872-018-0788-2Test

المؤلفون: Marília B. Gomes, Eduardo Tibiriçá, Diogo Van Bavel, Roger de Moraes

المصدر: BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, Nitroprusside, medicine.medical_specialty, Pathology, Endothelium, Intravital Microscopy, Vasodilator Agents, 030209 endocrinology & metabolism, Hyperemia, 030204 cardiovascular system & hematology, Microvascular rarefaction, Microcirculation, Exercise training, Fingers, 03 medical and health sciences, Laser Doppler flowmetry, 0302 clinical medicine, Internal medicine, Laser-Doppler Flowmetry, Medicine, Aerobic exercise, Humans, Endothelial dysfunction, Reactive hyperemia, Skin, Microscopy, Video, business.industry, Microvascular Density, Iontophoresis, medicine.disease, Acetylcholine, Capillaries, Exercise Therapy, Vasodilation, Forearm, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Treatment Outcome, Regional Blood Flow, Cardiology, Microvascular Rarefaction, Female, Endothelium, Vascular, business, Cardiology and Cardiovascular Medicine, Intravital microscopy, Research Article

الوصف: Background The aim of the present study was to evaluate changes in microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training. Methods This study included 22 (34 ± 7 years) consecutive outpatients with T1D and disease duration > 6 years. We used intravital video-microscopy to measure basal skin capillary density and capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers. Endothelium-dependent and -independent vasodilation of the skin microcirculation was evaluated in the forearm with a laser Doppler flow monitoring (LDF) system in combination with acetylcholine and sodium nitroprusside iontophoresis, PORH and local thermal hyperemia. Results The basal mean capillary density (MCD) after exercise training was significantly higher than before exercise (134 ± 25 vs. 119 ± 19 capillaries/mm2, respectively; P = 0.0013). MCD during PORH was also higher after exercise (140 ± 26 vs. 121 ± 24 capillaries/mm2, respectively; P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bbea1111df2c51b92e3d68ccb111e7Test
http://europepmc.org/articles/PMC4728937Test

المؤلفون: David Suran, Franjo Naji, Andreja Sinkovič

المصدر: BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, endocrine system diseases, Diabetic Cardiomyopathies, Systole, Ventricular Dysfunction, Right, Diastole, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Doppler imaging, Ventricular Function, Left, Both ventricles, 03 medical and health sciences, Ventricular Dysfunction, Left, Tissue Doppler imaging, 0302 clinical medicine, Diabetes mellitus type 1, Predictive Value of Tests, Internal medicine, medicine, Humans, Right ventricular dysfunction, Subclinical infection, Angiology, Echocardiography, Doppler, Pulsed, Observer Variation, Type 1 diabetes, Left ventricular dysfunction, business.industry, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Reproducibility of Results, Middle Aged, medicine.disease, Cardiac surgery, Cross-Sectional Studies, Diabetes Mellitus, Type 1, ROC Curve, Area Under Curve, Case-Control Studies, Cardiology, Ventricular Function, Right, Female, sense organs, business, Cardiology and Cardiovascular Medicine, Research Article

الوصف: Background Subclinical left (LV) and right ventricular (RV) dysfunction has been demonstrated in type 2 diabetes mellitus and evidence indicates impaired LV diastolic function in type 1 diabetes mellitus (T1DM) as well. The aim of our study was to evaluate the role of tissue Doppler imaging (TDI) in assessment of global LV and RV function in T1DM patients. Methods A detailed two-dimensional, pulsed wave Doppler and pulsed wave TDI analysis was performed in 53 normotensive middle-aged T1DM patients and compared to healthy controls. Results In T1DM patients TDI analysis revealed reduced mean mitral septal and lateral E’ velocities as well as reduced mean tricuspid E˙t velocity compared to healthy controls (E’sept 8.89 ± 1.89 cm/s vs. 11.50 ± 2.41 cm/s, p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aa96ce4d12055608cb809c6e6ed4baTest

المؤلفون: Dovile Razanskaite-Virbickiene, Rasa Verkauskiene, Rimante Dobrovolskiene, Giedre Mockeviciene, Rimantas Zalinkevicius, Evalda Danyte

المصدر: BMC Cardiovascular Disorders

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Supine position, Time Factors, Adolescent, Coefficient of variation, Cardiovascular autonomic neuropathy, Diaphragmatic breathing, 030209 endocrinology & metabolism, Spectral analysis, 030204 cardiovascular system & hematology, Autonomic Nervous System, Sudden death, Cardiovascular System, 03 medical and health sciences, Electrocardiography, Young Adult, 0302 clinical medicine, Diabetic Neuropathies, Heart Rate, Predictive Value of Tests, Internal medicine, Heart rate, Reflex, Autonomic reflex, medicine, Heart rate variability, Humans, Neurologic Examination, business.industry, food and beverages, Signal Processing, Computer-Assisted, Surgery, Type 1 diabetes, Diabetes Mellitus, Type 1, Autonomic Nervous System Diseases, ROC Curve, Cardiovascular Diseases, Predictive value of tests, Area Under Curve, Case-Control Studies, Cardiology, Respiratory Mechanics, Female, business, Cardiology and Cardiovascular Medicine, Research Article

الوصف: Background Cardiovascular autonomic neuropathy (CAN) increases morbidity and mortality in diabetes through association with a high risk of cardiac arrhythmias and sudden death, possibly related to silent myocardial ischemia. During the sub-clinical stage, CAN can be detected through reduction in heart rate variability (HRV). The aim of our study was to estimate if the time and frequency-domain analysis can be valuable for detecting CAN in young patients with type 1 diabetes mellitus (T1DM). Methods For this case control study of evaluation of cardiovascular autonomic function the 15–25 years age group of patients with duration of T1DM more than 9 years (n = 208, 89 males and 119 females) were selected. 67 patients with confirmed CAN were assigned to the “case group” and 141 patients without CAN served as a control group, the duration of T1DM was similar (15.07 ± 4.89 years vs.13.66 ± 4.02 years; p = 0.06) in both groups. Cardiovascular autonomic reflex tests and time and frequency domains analysis of HRV were performed for all subjects. Results Time domain measures were significantly lower in CAN group compared with control (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84aaa5c06132218337b42e7a5e314f59Test

المؤلفون: Peter Lwabi, Emmy Okello, Moses R. Kamya, Andrea Beaton, Chris T. Longenecker

المصدر: BMC Cardiovascular Disorders

مصطلحات موضوعية: Male, Time Factors, Heart disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Interquartile range, Atrial Fibrillation, Odds Ratio, Risk of mortality, Uganda, Prospective Studies, 030212 general & internal medicine, Child, Rheumatic heart disease, Mortality rate, 1. No poverty, Atrial fibrillation, Middle Aged, Prognosis, Anti-Bacterial Agents, 3. Good health, Child, Preschool, Cardiology, Rheumatic fever, Female, Cardiology and Cardiovascular Medicine, Research Article, Adult, medicine.medical_specialty, Adolescent, Outcomes, Risk Assessment, Drug Administration Schedule, Medication Adherence, Young Adult, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Mortality, Developing Countries, Proportional Hazards Models, Heart Failure, Chi-Square Distribution, Predictors, Proportional hazards model, business.industry, medicine.disease, Heart failure, Multivariate Analysis, Penicillin G Benzathine, Morbidity, business

الوصف: Background Rheumatic heart disease (RHD), the long-term consequence of rheumatic fever, accounts for most cardiovascular morbidity and mortality among young adults in developing countries. However, data on contemporary outcomes from resource constrained areas are limited. Methods A prospective cohort study of participants aged 5–60 years with established RHD was conducted in Kampala, Uganda, in which clinical exam, echocardiography, electrocardiography (ECG), and laboratory evaluation were done every 3 months and every 4-week benzathine penicillin prophylaxis was prescribed. Participants were followed up for 12 months and outcomes and predictors of morbidity and mortality were assessed using Kaplan Meier curves and Cox proportional hazards models. Results Of 449 subjects, 66.8% (300/449) were females, median age was 30 (interquartile range 20). 73.7% (331/449) had atleast one follow up visit. Among these, 35% (116/331) developed decompensated heart failure and, 63.7% (211/331) developed atrial fibrillation. Heart failure was associated with poor penicillin adherence (OR = 3.3, CI 2–5.4, p = 0.001), and left ventricular end diastolic diameter greater than 55 mm (OR = 3.16, CI 1.73–5.76, p = 0.001). Atrial fibrillation was associated with left atrial diameter >40 mm (OR = 7.5, CI 2.4–9.8, p = 0.001). There were 59 deaths with a 1-year mortality rate of 17.8%. Most deaths occurred within the first three months of presentation. Subjects whose average adherence to benzathine penicillin was

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bddf4b89d25333664360226417f64daTest