التفاصيل البيبلوغرافية
| العنوان: |
Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients. |
| المؤلفون: |
McEvoy, Ashleigh C., Warburton, Lydia, Al-Ogaili, Zeyad, Celliers, Liesl, Calapre, Leslie, Pereira, Michelle R., Khattak, Muhammad A., Meniawy, Tarek M., Millward, Michael, Ziman, Melanie, Gray, Elin S. |
| المصدر: |
BMC Cancer; 7/9/2018, Vol. 18 Issue 1, p1-8, 8p, 2 Charts, 4 Graphs |
| مصطلحات موضوعية: |
CIRCULATING tumor DNA, TUMORS, MELANOMA, METASTASIS, POSITRON emission tomography, COMPUTED tomography, POLYMERASE chain reaction |
| مستخلص: |
Background: Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients' overall metabolic tumour burden (MTB).Methods: Thirty-two treatment naïve metastatic melanoma patients were included in the study. MTB and metabolic tumour volume (MTV) was measured by 18F-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT). Plasma ctDNA was quantified using droplet digital PCR (ddPCR).Results: CtDNA was detected in 23 of 32 patients. Overall, a significant correlation was observed between ctDNA levels and MTB (p < 0.001). CtDNA was not detectable in patients with an MTB of ≤10, defining this value as the lower limit of tumour burden that can be detected through ctDNA analysis by ddPCR.Conclusions: We showed that ctDNA levels measured by ddPCR correlate with MTB in treatment naïve metastatic melanoma patients and observed a limit in tumour size for which ctDNA cannot be detected in blood. Nevertheless, our findings support the use of ctDNA as a non-invasive complementary modality to functional imaging for monitoring tumour burden. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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