التفاصيل البيبلوغرافية
| العنوان: |
Trastuzumab-induced corneal ulceration: successful no-drug treatment of a "blind" side effect in a case report. |
| المؤلفون: |
Orlandi, A., Fasciani, R., Cassano, A., Agresta, A., Calegari, M. A., Caporossi, A., Barone, C. |
| المصدر: |
BMC Cancer; 12/16/2015, Vol. 15, p1-3, 3p, 2 Color Photographs |
| مصطلحات موضوعية: |
TRASTUZUMAB, CORNEAL ulcer, BREAST cancer, IMMUNOGLOBULINS, DRUG side effects, BLOOD serum analysis |
| مستخلص: |
Background: We report the first successful treatment of limbal lesions and corneal erosion experienced by a breast cancer patient undergoing trastuzumab treatment.Case Presentation: A 49-year-old Caucasian woman with early stage breast cancer was treated with adjuvant trastuzumab and subsequently showed persistent bilateral corneal marginal infiltrates resistant to topical steroid and antibiotic treatment. Autologous serum was applied in the conjunctival sac as an experimental treatment to antagonize the inhibitory effect of the HER2 receptor antibody on the corneal epithelial cells. Topical application of autologous serum led to rapid improvement of the ulcerative keratitis, with complete healing of the corneal defect after 7 days. Continued administration of the serum allowed the resumption of trastuzumab therapy without any further side effects.Conclusions: Persistent bilateral corneal marginal infiltrates may occasionally arise as a side effect of trastuzumab treatment. Topical medication with autologous serum may be an effective therapeutic option for the ocular side effects of trastuzumab therapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder