المؤلفون: Shujing Shen, Ruipan Zheng, Peizhu Hu, Xingya Li, Ziheng Zhang, Yurong Wang

المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Cancer

مصطلحات موضوعية: Oncology, Male, Cancer Research, Lung Neoplasms, EGFR TKI, medicine.disease_cause, NSCLC, T790M, Exon, Resistance mechanism, Surgical oncology, Clinical outcomes, Carcinoma, Non-Small-Cell Lung, Epidermal growth factor receptor, RC254-282, EGFR inhibitors, education.field_of_study, Mutation, Aniline Compounds, biology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Exons, Middle Aged, Progression-Free Survival, ErbB Receptors, Disease Progression, Female, Research Article, Adult, medicine.medical_specialty, Genotype, Population, Internal medicine, Genetics, medicine, Humans, education, Protein Kinase Inhibitors, Aged, Retrospective Studies, Acrylamides, business.industry, Retrospective cohort study, Genes, erbB-1, Mutagenesis, Insertional, EGFR exon 19 deletion-insertion, biology.protein, business, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afcb5b82c72a100d035448232dbecdcTest
https://pubmed.ncbi.nlm.nih.gov/34774017Test

المؤلفون: Junji Uchino, Wataru Furutani, Akihiro Yoshimura, Tadaaki Yamada, Takayuki Takeda, Naoya Nishioka, Yusuke Chihara, Naoko Okura, Koichi Takayama, Yutaka Kubota, Shinsuke Shiotsu, Yoshiko Kaneko, Nobuyo Tamiya, Osamu Hiranuma

المصدر: BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-6 (2018)

مصطلحات موضوعية: Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Biopsy, Population, lcsh:RC254-282, 03 medical and health sciences, T790M, Tumor shrinkage, 0302 clinical medicine, Refractory, Non-small cell lung cancer, Surgical oncology, Internal medicine, Carcinoma, Non-Small-Cell Lung, Genetics, Medicine, Humans, 030212 general & internal medicine, Lung cancer, education, Protein Kinase Inhibitors, EGFR inhibitors, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, business.industry, Odds ratio, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, respiratory tract diseases, ErbB Receptors, EGFR-T790M mutation, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Mutation, Female, Re-biopsy, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d399b9c30929e660f83f14d0ad18fa1Test
http://europepmc.org/articles/PMC6288862Test

المؤلفون: Qamar Javed, Miroslav Blumenberg, Sidra Younis

المصدر: BMC Cancer

مصطلحات موضوعية: Cancer Research, Angiogenesis, Antineoplastic Agents, Biology, Targeted therapy, ErbB Receptors, Gefitinib, ErbB, Cell Line, Tumor, Databases, Genetic, Genetics, medicine, Humans, Epidermal growth factor receptor, Protein Kinase Inhibitors, EGFR inhibitors, Cell cycle, Gene Expression Regulation, Neoplastic, Erlotinib, Oncology, Drug Resistance, Neoplasm, Metabolic changes, Mutation, Cancer research, biology.protein, Tyrosine kinase, Research Article, Development of resistance, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28473820b74736f2fbc00578949ef9eeTest
https://doi.org/10.1186/s12885-015-1337-3Test

المؤلفون: Elena Gallego, Vanessa de Luque, Nuria Ribelles, Luis Vicioso, José Manuel Lozano, Emilio Alba, Alfonso Sánchez-Muñoz, Luis G. Perez-Rivas

المساهمون: [Sánchez-Muñoz,A, Ribelles Entrena,N, Alba Conejo,E] Servicio de Oncología Médica, Hospital Universitario Virgen de la Victoria, Málaga, España. [Gallego Domínguez,E, Vicioso Recio,L] Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Victoria, Málaga, España. [Sánchez-Muñoz,A, Gallego Domínguez,EM, Luque,V de, Pérez-Rivas,LG, Vicioso Recio,L, Lozano Castro,J, Alba Conejo,E] Laboratorio de Investigación Biomédica (LIB-IMABIS), Hospital Universitario Virgen de la Victoria, Málaga, España. [Lozano Castro,J] Dpto. de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, España., This work was supported by Fondo de Investigaciones Sanitarias grant PI081797 (to E. A.) and Ministerio de Ciencia e Innovación grant BFU2007-66100 (to J. L.).

المصدر: BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 136 (2010)

مصطلحات موضوعية: Cancer Research, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors [Medical Subject Headings], Colorectal cancer, Receptor, ErbB-2, KRAS protein, human, Marcadores tumorales, DNA Mutational Analysis, medicine.disease_cause, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::GTP Phosphohydrolases::GTP-Binding Proteins::Monomeric GTP-Binding Proteins::ras Proteins [Medical Subject Headings], Polymerase Chain Reaction, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases::Receptor, erbB-2 [Medical Subject Headings], KRT5 protein, human, Surgical oncology, Análisis Mutacional de ADN, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis [Medical Subject Headings], Triple-negative breast cancer, EGFR inhibitors, Cetuximab, Queratina-5, Marcadores biológicos de tumor, Proteínas ras, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Neoplasms, Basal Cell [Medical Subject Headings], Queratina-6, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Proteínas Proto-Oncogénicas, Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Intermediate Filament Proteins::Keratins::Keratins, Type II::Keratin-5 [Medical Subject Headings], ErbB Receptors, Gene Expression Regulation, Neoplastic, Oncology, Receptors, Estrogen, Neoplasias de la mama, Inhibidores de las Proteína Quinasas, Health Care::Health Services Administration::Patient Care Management::Patient Selection [Medical Subject Headings], Neoplasias vasocelulares, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytochemistry::Immunohistochemistry [Medical Subject Headings], Female, KRAS, Chemicals and Drugs::Biological Factors::Biological Markers::Tumor Markers, Biological [Medical Subject Headings], Receptors, Progesterone, medicine.drug, Research Article, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Receptores estrogénicos, Selección de pacientes, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Progesterone [Medical Subject Headings], Breast Neoplasms, Receptores de progesterona, Biology, lcsh:RC254-282, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Estrogen [Medical Subject Headings], Proto-Oncogene Proteins p21(ras), EGFR protein, human, Breast cancer, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases::Receptor, Epidermal Growth Factor [Medical Subject Headings], Proto-Oncogene Proteins, medicine, Genetics, Biomarkers, Tumor, Panitumumab, Humans, Protein Kinase Inhibitors, Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings], Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Intermediate Filament Proteins::Keratins::Keratins, Type II::Keratin-6 [Medical Subject Headings], Neoplasms, Basal Cell, Mutación, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins [Medical Subject Headings], Patient Selection, Keratin-6, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction [Medical Subject Headings], ERBB2 protein, human, medicine.disease, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic [Medical Subject Headings], Receptor del Factor de Crecimiento Epidérmico, Check Tags::Female [Medical Subject Headings], Mutation, Reacción en Cadena de la Polimerasa, Cancer research, ras Proteins, Keratin-5, Regulación Neoplásica de la Expresión Génica, Inmunohistoquímica

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0053436b9a3dc24d859a30fbdf1cd8e8Test
https://pubmed.ncbi.nlm.nih.gov/20385028Test

المؤلفون: Esther P. Black, Justin M. Balko

المصدر: BMC Cancer
BMC Cancer, Vol 9, Iss 1, p 145 (2009)

مصطلحات موضوعية: Cancer Research, Genotype, Colorectal cancer, medicine.medical_treatment, Cetuximab, Antibodies, Monoclonal, Humanized, medicine.disease_cause, lcsh:RC254-282, Disease-Free Survival, Targeted therapy, Predictive Value of Tests, Surgical oncology, Genetics, Humans, Medicine, Progression-free survival, Neoplasm Metastasis, neoplasms, EGFR inhibitors, business.industry, Gene Expression Profiling, Antibodies, Monoclonal, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, digestive system diseases, respiratory tract diseases, ErbB Receptors, Gene Expression Regulation, Neoplastic, Oncology, Mutation, ras Proteins, Cancer research, KRAS, Erlotinib, Colorectal Neoplasms, business, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3141eabefb7ae5339a879ab5ee4169dTest
https://doi.org/10.1186/1471-2407-9-145Test

المؤلفون: Stephen B. Fox, Hongdo Do, Paul Mitchell, Alexander Dobrovic, Michael Krypuy

المصدر: BMC Cancer
BMC Cancer, Vol 8, Iss 1, p 142 (2008)

مصطلحات موضوعية: Male, Cancer Research, Lung Neoplasms, Biopsy, DNA Mutational Analysis, lcsh:RC254-282, Sensitivity and Specificity, High Resolution Melt, Cohort Studies, Proto-Oncogene Proteins p21(ras), Gefitinib, Growth factor receptor, Epidermal growth factor, Carcinoma, Non-Small-Cell Lung, Proto-Oncogene Proteins, Genetics, medicine, Humans, Transition Temperature, Epidermal growth factor receptor, Genetic Testing, EGFR inhibitors, Paraffin Embedding, biology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Molecular biology, ErbB Receptors, Oncology, Mutation (genetic algorithm), Mutation, biology.protein, ras Proteins, Adenocarcinoma, Female, medicine.drug, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f02fe8bb8c7237ef6d0c405020486bTest
http://europepmc.org/articles/PMC2408599Test

المؤلفون: Raquel Seruca, Fátima Carneiro, Gianpaolo Suriano, Ana Rita Mateus, Catia Moutinho, Fernanda Milanezi

المصدر: BMC Cancer
BMC Cancer, Vol 8, Iss 1, p 10 (2008)

مصطلحات موضوعية: Adult, Male, Cancer Research, DNA Mutational Analysis, Antineoplastic Agents, Biology, lcsh:RC254-282, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Gene duplication, Genetics, Carcinoma, medicine, Humans, EGFR Gene Amplification, Epidermal growth factor receptor, Protein Kinase Inhibitors, In Situ Hybridization, Fluorescence, 030304 developmental biology, EGFR inhibitors, Aged, 0303 health sciences, Polysomy, Polymorphism, Genetic, Patient Selection, Gene Amplification, Cancer, Exons, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Introns, 3. Good health, ErbB Receptors, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Female, Tyrosine kinase, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2868cb828391f54734301d331e7c9ab8Test
http://europepmc.org/articles/PMC2244615Test

المؤلفون: Miguel Carballo, Angels Arcusa, Miguel Miranda de Sousa Dias, Miguel Blanca, Emma Borràs, Ismael Jurado, Begoña Mañé, José A. G. Agúndez, Imma Hernan, Isabel Martí, María José Gamundi

المساهمون: [Borràs, E, Hernan,I, Gamundi,MJ, Dias,M, Martí,I, Mañé,B, Carballo,M] Molecular Genetics Unit, Hospital de Terrassa. [Jurado,I] Pathology Service, Hospital de Terrassa. [Arcusa,A] Oncology Service, Hospital de Terrassa. [Agúndez, JAG] Department of Pharmacology, Universidad de Extremadura. [Blanca,M] Allergy Service, Hospital Carlos Haya., This work was supported by grants from Spanish Health Ministry (FIS) network RIRAAF (RD 07/0064).

المصدر: BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 406 (2011)

مصطلحات موضوعية: Cancer Research, DNA Mutational Analysis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing [Medical Subject Headings], medicine.disease_cause, Chemicals and Drugs::Biological Factors [Medical Subject Headings], Neoplasms, Análisis Mutacional de ADN, Epidermal growth factor receptor, Molecular Targeted Therapy, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis [Medical Subject Headings], Factores Biológicos, EGFR inhibitors, Cetuximab, High-Throughput Nucleotide Sequencing, Diseases::Neoplasms [Medical Subject Headings], lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Neoplasias, ErbB Receptors, Terapia Molecular Dirigida, Oncology, Erlotinib, KRAS, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Monomeric GTP-Binding Proteins::ras Proteins [Medical Subject Headings], Tyrosine kinase, medicine.drug, Research Article, Proto-Oncogene Proteins B-raf, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence [Medical Subject Headings], Molecular Sequence Data, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Molecular Targeted Therapy [Medical Subject Headings], Biology, lcsh:RC254-282, Sensitivity and Specificity, Proto-Oncogene Proteins p21(ras), Gefitinib, Alineación de Secuencia, Proto-Oncogene Proteins, medicine, Genetics, Humans, neoplasms, Base Sequence, Cancer, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Peptide::Receptors, Growth Factor::Receptor, Epidermal Growth Factor [Medical Subject Headings], Reproducibility of Results, Phenomena and Processes::Mathematical Concepts::Sensitivity and Specificity [Medical Subject Headings], medicine.disease, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Alignment [Medical Subject Headings], digestive system diseases, Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::MAP Kinase Kinase Kinases::raf Kinases::Proto-Oncogene Proteins B-raf [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Reproducibility of Results [Medical Subject Headings], Mutation, Cancer research, biology.protein, ras Proteins, Sequence Alignment, Secuencia de Bases

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47129b87b5a305f0fb4fbdeb9dc961b5Test