Carbon ion radiotherapy for 80 years or older patients with hepatocellular carcinoma
| العنوان: | Carbon ion radiotherapy for 80 years or older patients with hepatocellular carcinoma |
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| المؤلفون: | Hiroyuki Katoh, Yoshinori Koyama, Takashi Nakano, Satoru Kakizaki, Kei Shibuya, Takanori Abe, Hirohumi Shimada, Shintaro Shiba, Ken Shirabe, Tatsuya Ohno, Hiroyuki Kuwano |
| المصدر: | BMC Cancer BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Hepatocellular carcinoma, medicine.medical_treatment, Heavy Ion Radiotherapy, Gastroenterology, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Internal medicine, Genetics, medicine, Humans, Carbon-ion radiotherapy, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, Performance status, Radiotherapy, business.industry, Liver Neoplasms, Cancer, Magnetic resonance imaging, Retrospective cohort study, Common Terminology Criteria for Adverse Events, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Survival Analysis, Surgery, Radiation therapy, Elderly patients, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Disease Progression, 030211 gastroenterology & hepatology, Female, Dose Fractionation, Radiation, business, Research Article |
| الوصف: | To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) for 80 years or older patients with hepatocellular carcinoma (HCC). Eligibility criteria of this retrospective study were: 1) HCC confirmed by histology or typical hallmarks of HCC by imaging techniques of four-phase multidetector-row computed tomography or dynamic contrast-enhanced magnetic resonance imaging; 2) no intrahepatic metastasis or distant metastasis; 3) no findings suggesting direct infiltration of the gastrointestinal tract; 4) performance status ≤2 by Eastern Cooperative Oncology Group classification; and 5) Child-Pugh classification A or B. Patients received C-ion RT with 52.8 Gy (RBE) or 60.0 Gy (RBE) in four fractions for usual cases and 60.0 Gy (RBE) in 12 fractions for close-to-gastrointestinal tract cases. Toxicities were classified using the National Cancer Institute’s Common Terminology Criteria for Adverse Events (Version 4.0). Between March 2011 and November 2015, 31 patients were treated. The median follow-up period of all patients was 23.2 months (range: 8.4–55.3 months). Median age at the time of registration of C-ion RT was 83 years (range: 80–95 years). Child-Pugh grade A and B were 27 patients and 4 patients, respectively. The 2-year estimated overall survival, local control, and progression-free survival rates were 82.3%, 89.2%, and 51.3%, respectively. No patients had Grade 2 or higher acute toxicities (within 3 months after C-ion RT). One patient experienced progression in Child-Pugh classification from A to B within 3 months after C-ion RT. In late toxicities, Grade 3 encephalopathy was observed in 3 patients, and 2 improved with medication. C-ion RT was effective with minimal toxicities for 80 years or older patients with hepatocellular carcinoma. UMIN000020571 : date of registration, 14 January 2016, retrospectively registered. |
| تدمد: | 1471-2407 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb0f280dbd9751ce8b19dfd43b202a6Test https://pubmed.ncbi.nlm.nih.gov/29115938Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dfb0f280dbd9751ce8b19dfd43b202a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712407 |
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