High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma
| العنوان: | High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma |
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| المؤلفون: | Takamichi Igarashi, Tetsunari Oyama, Dolgormaa Gantumur, Kyoichi Ogata, Mariko Tsukagoshi, Toshiaki Hikino, Takayoshi Watanabe, Akira Watanabe, Norio Kubo, Takahiro Yamanaka, Ayaka Katayama, Hiroyuki Kuwano, Norifumi Harimoto, Yasunari Ubukata, Takehiko Yokobori, Takaaki Sano, Tadashi Handa, Ken Shirabe, Kei Hagiwara, Yuki Shimoda, Kenichiro Araki |
| المصدر: | BMC Cancer BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018) |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cancer Research, Carcinoma, Hepatocellular, Epithelial-Mesenchymal Transition, Kaplan-Meier Estimate, Malignancy, lcsh:RC254-282, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Biomarkers, Tumor, Genetics, medicine, Humans, Epithelial–mesenchymal transition, HCC, Aged, Aged, 80 and over, biology, business.industry, Cadherin, Liver Neoplasms, Cell Differentiation, Forkhead Transcription Factors, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, medicine.disease, digestive system diseases, Up-Regulation, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Liver, Epithelial-to-mesenchymal transition, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, biology.protein, Cancer research, FOXC2, Immunohistochemistry, Female, business, Research Article |
| الوصف: | Background Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion and metastasis, and the forkhead box protein C2 (FOXC2) has been shown to promote tumor cell proliferation, invasion, and EMT. In the present study, we examined the clinicopathological significance of FOXC2 and EMT-related markers in clinical HCC specimens and identified factors related to the diagnosis and prognosis of HCC. Methods The expression of FOXC2 and EMT-related markers was evaluated by immunohistochemistry in 84 cases of hepatocellular carcinoma. Results A high expression of FOXC2 was observed in 26 of 84 cases, and expression was significantly correlated with background liver cirrhosis, poor tumor differentiation, high serum AFP, and elevated cell proliferation markers. In addition, this high expression was related to the induction of the Cadherin switch and vimentin expression and was an independent predictor for poor prognosis. Conclusion The high expression of FOXC2 in HCC is correlated with tumor malignancy and poor prognosis, suggesting that FOXC2 may be an important prognostic factor for HCC. |
| تدمد: | 1471-2407 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1441aec322f09f7e48b8039466c50d0eTest https://doi.org/10.1186/s12885-018-4503-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1441aec322f09f7e48b8039466c50d0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712407 |
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