التفاصيل البيبلوغرافية
| العنوان: |
The Role of Uremic Retention Solutes in the MIA Syndrome in Hemodialysis Subjects. |
| المؤلفون: |
Ciceri, Paola, Artioli, Luisa, Magagnoli, Lorenza, Barassi, Alessandra, Alvarez, Jean-Claude, Massy, Ziad A., Galassi, Andrea, Cozzolino, Mario |
| المصدر: |
Blood Purification; 2023, Vol. 52 Issue 1, p41-53, 13p |
| مصطلحات موضوعية: |
BLOOD cholesterol, CARDIOVASCULAR diseases, VASCULAR smooth muscle, KIDNEY calcification, SYNDROMES, CARDIOVASCULAR disease related mortality, CHRONIC kidney failure |
| مستخلص: |
Introduction: In chronic kidney disease (CKD), the high morbidity and mortality risk for cardiovascular disease (CVD) are not easily explained only on the basis of traditional factors. Among nontraditional ones involved in CKD, malnutrition, inflammation, and atherosclerosis/calcification have been described as the "MIA syndrome." Methods: In this pilot study, we evaluated the association between the variation in serum levels of 27 uremic retention solutes plus 6 indexes related to the MIA syndrome processes in a population of dialysis patients. Results: As expected, we found a direct correlation between serum albumin and both phosphate and total cholesterol (r = 0.54 and 0.37, respectively; p < 0.05). Moreover, total cholesterol and phosphate directly correlate (r = 0.40, p < 0.05). The relationship between malnutrition and inflammation is highlighted by the correlation of serum cholesterol levels with serum alpha-1 acid glycoprotein and IL-6 levels (r = −0.56, r = −0.39, respectively; p < 0.05). Moreover, the relation between inflammation and atherosclerosis/calcification is supported by the correlation of IL-6 with VEGF levels and vascular smooth muscle cell high-Pi in vitro calcification (r = 0.81, r = 0.66, respectively; p < 0.01). Conclusion: We found significant correlations between several uremic retention solutes and malnutrition, inflammation, and atherosclerosis/calcification. Our findings support the hypothesis of a central role of the uremic milieu in the MIA syndrome and ultimately in the pathogenesis of CKD-specific CVD risk factors. [ABSTRACT FROM AUTHOR] |
|
Copyright of Blood Purification is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
