دورية
Feeding the Fire: The Comorbid and Inflammatory Backdrop of Clonal Hematopoiesis of Indeterminate Potential (CHIP) By Mutation Subtype
| العنوان: | Feeding the Fire: The Comorbid and Inflammatory Backdrop of Clonal Hematopoiesis of Indeterminate Potential (CHIP) By Mutation Subtype |
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| المؤلفون: | Cook, Elina K, Izukawa, Terumi, Young, Sherylan, Rosen, Gili, Jamali, Mina, Snetsinger, Brooke, Johnson, Dylan, Bain, Eva, Hilland, Jamie, Buckstein, Jonah, Francis, Janika, Momtaz, Bushra, Buckstein, Rena, Rauh, Michael J. |
| المصدر: | Blood; December 2017, Vol. 130 Issue: 1, Number 1 Supplement 1 p426-426, 1p |
| مستخلص: | Clonal hematopoiesis of indeterminate potential/aging (CHIP) is a potential precursor to MDS and myeloid cancer; it is also associated with comorbid cardiometabolic diseases that may be exacerbated by inflammation. The top mutated genes in CHIP are TET2and DNMT3A(Buscarlet, Blood 2017). Tet2-mutated (deficient) macrophages may contribute to a pro-inflammatory environment (Cull, Exp Hematol 2017), including increased IL-6 (Fuster, Science 2017). Moreover, we found that Tet2-deficient hematopoietic stem cells thrive in an inflammatory environment in vitro, while Tet2 wild-type hematopoietic stem cells are suppressed (Abegunde, ASH 2016). |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V130.Suppl_1.426.426 |