دورية
Inhibition of c-kitLigand/Steel Factor by Antibodies Reduces Survival of Lethally Irradiated Mice
| العنوان: | Inhibition of c-kitLigand/Steel Factor by Antibodies Reduces Survival of Lethally Irradiated Mice |
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| المؤلفون: | Neta, Ruth, Williams, Douglas, Selzer, Faith, Abrams, John |
| المصدر: | Blood; January 1993, Vol. 81 Issue: 2 p324-327, 4p |
| مستخلص: | Survival after irradiation with LD100/30(radiation dose lethal to 100% of mice in 30 days) is based on recovery of impaired hematopoietic function. Our previous studies using antibodies to interleukin-1 receptor (IL-1R), tumor necrosis factor (TNF), and IL-6 demonstrated that endogenous production of these three cytokines is required for untreated mice as well as mice protected with lipopolysaccharide (LPS), IL-1, or TNF to survive lethal irradiation. In this report we show that anti–c-kitligand/steel factor (SIF) antibody similarly abrogates LPS- and IL-1–induced radioprotection. Furthermore, administration of this antibody to unmanipulated mice increased LD50/30radiation lethality from 50% to 100%. Such an effect was not obtained using anti–IL-3, anti–IL-4, or anti–granulocyte-macrophage colony-stimulating factor antibody. Thus, like IL-1, TNF, and IL-6, SIF is required for survival from lethal irradiation. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V81.2.324.324 |