Human fetuses are able to mount an adultlike CD8 T-cell response
| العنوان: | Human fetuses are able to mount an adultlike CD8 T-cell response |
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| المؤلفون: | Patricia Rodriguez, Aurélie Berthe, Yves Carlier, Jos Even, Eric Gonzalez-Merino, Emmanuel Hermann, Cristina Alonso-Vega, Faustino Torrico, Carine Truyens |
| المصدر: | Blood. 100:2153-2158 |
| بيانات النشر: | American Society of Hematology, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Receptors, Antigen, T-Cell, alpha-beta, Trypanosoma cruzi, Immunology, Apoptosis, CD8-Positive T-Lymphocytes, Biology, Biochemistry, Fetus, Immune system, Antigen, Animals, Humans, Cytotoxic T cell, Receptor, Immunity, Infant, Newborn, Cell Differentiation, Cell Biology, Hematology, Fetal Blood, Flow Cytometry, biology.organism_classification, Complementarity Determining Regions, Virology, Interleukin 15, CD8 |
| الوصف: | Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activation markers and armed to mediate effector functions. The analysis of the T-cell receptor beta chain variable repertoire shows the oligoclonal expansion of these T lymphocytes, indicating that activation was driven by parasite antigens. Indeed, we have detected parasite-specific CD8 T cells secreting interferon-γ after coincubation with live T cruzi. This response is enhanced in the presence of recombinant interleukin-15, which limits the T-cell spontaneous apoptosis. These findings point out that the fetal immune system is more competent than previously appreciated, since fetuses exposed to live pathogens are able to develop an adultlike immune CD8 T-cell response. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42e6707e28b6187d707c0a905cb3904Test https://doi.org/10.1182/blood.v100.6.2153Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a42e6707e28b6187d707c0a905cb3904 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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