دورية
Microrna-15a-5p Regulates Multiple Components of GPVI-Mediated Platelet and Megakaryocyte Activation Pathway
| العنوان: | Microrna-15a-5p Regulates Multiple Components of GPVI-Mediated Platelet and Megakaryocyte Activation Pathway |
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| المؤلفون: | Basak, Indranil, Bhatlekar, Seema, Campbell, Robert A., Chahdi, Ahmed, Kong, Xianguo, Ma, Lin, Rondina, Matthew T., Weyrich, Andrew S., Edelstein, Leonard C., Bray, Paul F. |
| المصدر: | Blood; December 2017, Vol. 130 Issue: 1, Number 1 Supplement 1 p1021-1021, 1p |
| مستخلص: | Introduction:Platelet activation by collagen is a major effector ofnormal hemostasis. Mutations in GPVI, the major collagen signaling receptor, cause platelet-type bleeding. Two single nucleotide polymorphisms in GPVI have been identified as risk factors for myocardial infarction. Elevated levels of GPVI have been reported in patients with coronary syndromes. GPVI and its signaling pathway components for platelet activation have become potential antithrombotic targets. Reports have indicated microRNAs (miRs) regulate platelet activation, but none have considered the mechanisms involving miR-mRNA associations regulating the GPVI-mediated platelet activation pathway. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V130.Suppl_1.1021.1021 |