Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas
| العنوان: | Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas |
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| المؤلفون: | Patty M. Jansen, Johan H. J. M. van Krieken, Jettie J.F. Muris, Saskia A. G. M. Cillessen, Joost J. Oudejans, N. Mehdi Jiwa, Hanneke C. Kluin-Nelemans, J. Alain Kummer, Wim Vos, Chad Gundy, Gert J. Ossenkoppele, Inge S. van Houdt, Chris J.L.M. Meijer |
| المساهمون: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL) |
| المصدر: | Blood, 105, 2916-23 Blood, 105(7), 2916-2923. AMER SOC HEMATOLOGY Blood, 105, 7, pp. 2916-23 |
| بيانات النشر: | AMER SOC HEMATOLOGY, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Genetics and epigenetic pathways of disease [NCMLS 6], CASP8 and FADD-Like Apoptosis Regulating Protein, C-FLIP, Apoptosis, Biochemistry, ACTIVATION, Medicine, ELDERLY-PATIENTS, Caspase, Etoposide, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], INDUCED APOPTOSIS, Aged, 80 and over, Caspase-9, Caspase 8, biology, Caspase 3, Intracellular Signaling Peptides and Proteins, DEATH, Hematology, Middle Aged, Immunohistochemistry, Caspase 9, XIAP, Treatment Outcome, Proto-Oncogene Proteins c-bcl-2, Caspases, Female, Lymphoma, Large B-Cell, Diffuse, Poly(ADP-ribose) Polymerases, Signal Transduction, Adult, EXPRESSION, Lymphoma, B-Cell, Age-related aspects of cancer [ONCOL 2], Adolescent, Immunology, X-Linked Inhibitor of Apoptosis Protein, Inhibitor of apoptosis, Translational research [ONCOL 3], Humans, NON-HODGKINS-LYMPHOMA, REED-STERNBERG CELLS, Aged, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Proteins, Cell Biology, medicine.disease, Antineoplastic Agents, Phytogenic, biology.protein, Cancer research, Caspase 10, FLICE-INHIBITORY PROTEIN, business, Diffuse large B-cell lymphoma, RESISTANCE |
| الوصف: | Contains fulltext : 47593.pdf (Publisher’s version ) (Closed access) We used biopsy specimens of primary nodal diffuse large B-cell lymphoma (DLBCL) to investigate whether the inhibition of caspase 8 and/or 9 apoptosis signaling pathways predicts clinical outcome. Expression levels of cellular FLICE inhibitory protein (c-Flip) and numbers of active caspase 3-positive lymphoma cells were used to determine the status of the caspase 8-mediated pathway. Expression levels of Bcl-2 and X-linked inhibitor of apoptosis (XIAP) were used to determine the status of the caspase 9-mediated pathway. Expression of c-Flip, XIAP, Bcl-2, and caspase 3 activity all provided prognostic information. According to these immunohistochemical parameters, inhibition of either or both caspase signaling pathways was detected in all patients. Three groups of patients were identified, one with a caspase 8 inhibition profile, one with caspase 8 and 9 inhibition profiles, and one with a caspase 9 inhibition profile. Caspase 9 inhibition was strongly associated with poor response to chemotherapy and usually with fatal outcome, whereas caspase 8 inhibition was associated with excellent clinical outcome. Thus, our data strongly suggest that inhibition of the caspase 9-mediated pathway, but not the caspase 8-mediated pathway, is a major cause for therapy resistance in patients with nodal DLBCL. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974091f988c3246d74764f9facf68350Test https://research.rug.nl/en/publications/af253972-9b53-45fe-9afc-9900dfcb9e40Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....974091f988c3246d74764f9facf68350 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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