التفاصيل البيبلوغرافية
| العنوان: |
Integration of neoadjuvant and adjuvant chemotherapy and cystectomy in the treatment of muscle-invasive bladder cancer. |
| المؤلفون: |
Milowsky, Matthew I.1,2 milowskm@mskcc.org, Stadler, Walter M.3, Bajorin, Dean F.1,2 |
| المصدر: |
BJU International. Nov2008, Vol. 102 Issue 9 Pt. B, p1339-1344. 6p. |
| مصطلحات موضوعية: |
*CANCER invasiveness, *ADJUVANT chemotherapy, *NEOADJUVANT chemotherapy, *BLADDER cancer, *CYSTECTOMY, *UROTHELIUM |
| مستخلص: |
Bladder cancer is a potentially curable malignancy but for those patients who present with or develop muscle-invasive disease, there is a high risk of metastases and cancer-related death. The treatment of patients with muscle-invasive bladder cancer uses a multimodal approach, including radical cystectomy with pelvic lymph node dissection and perioperative chemotherapy. Neoadjuvant cisplatin combination chemotherapy has a modest survival benefit, with those patients achieving a complete pathological response after chemotherapy having the best outcome. Adjuvant chemotherapy, although less well substantiated, is a reasonable option for patients with extravesical disease or lymph node involvement after cystectomy. Perioperative chemotherapy is substantially underused despite the level-1 evidence showing a survival benefit. Ongoing research will focus on individualized patient care, with biomarkers to predict a pathological complete response and the development of novel targeted therapies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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