CircLMTK2 acts as a novel tumor suppressor in gastric cancer
| العنوان: | CircLMTK2 acts as a novel tumor suppressor in gastric cancer |
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| المؤلفون: | Ben Ma, Li Jiang, Jian He, Jie Chen, Guangfa Zhao |
| المصدر: | Bioscience Reports |
| بيانات النشر: | Portland Press Ltd., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Biophysics, Biology, survival, Biochemistry, Disease-Free Survival, law.invention, cell migration and invasion, 03 medical and health sciences, Exon, 0302 clinical medicine, Stomach Neoplasms, Circular RNA, law, Cell Line, Tumor, Biological property, medicine, Humans, Genes, Tumor Suppressor, RNA, Neoplasm, Viability assay, Molecular Biology, Research Articles, gastric cancer, Cancer, circular RNA, RNA, Circular, Cell Biology, medicine.disease, LMTK2 Gene, Survival Rate, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Suppressor, Biomarker (medicine), Female, Research Article |
| الوصف: | Recently, circRNAs have been found to play regulatory roles in cancer. In the present study, we aimed to investigate the characteristics and effect of circLMTK2, and its potential role as a novel biomarker in cases of gastric cancer (GC). About 111 pairs of clinical tissues from patients were collected for circLMTK2 expression investigation. Afterward, the relationship of circLMTK2 expression level and clinical features, such as survival, tumor size and so on, were analyzed, along with a multivariate Cox hazards analysis. Finally, malignant biological properties, like cell viability and mobility, were explored in cell line MGC-803. We found that circLMTK2 was a stable circRNA generated from the back-spliced Exon 10 and Exon 11 of the LMTK2 gene in GC cells. CircLMTK2 expression was significantly down-regulated in gastric carcinoma tissue specimens (P |
| تدمد: | 1573-4935 0144-8463 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6889f8945c17450dd8b5e81dd176b331Test https://doi.org/10.1042/bsr20190363Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6889f8945c17450dd8b5e81dd176b331 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734935 01448463 |
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