دورية أكاديمية
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
| العنوان: | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
|---|---|
| المؤلفون: | Romitti, Mirian, De Faria Da Fonseca, Barbara, Doumont, Gilles, Gillotay, Pierre, Tourneur, Adrien, Eski, Sema Elif, Van Simaeys, Gaëtan, Chomette, Laura, Lasolle, Hélène, Monestier, Olivier, Figini Kasprzyk, Dominika, Detours, Vincent, Singh, Sumeet Pal, Goldman, Serge, Refetoff, Samuel, Costagliola, Sabine |
| المصدر: | BioRxiv |
| سنة النشر: | 2021 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences biomédicales |
| الوصف: | The function of the thyroid gland is to capture iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans which is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, there is a need for new therapeutic approaches that involve replacement of thyroid tissue responsive to changing demands for thyroid hormone. Here we report the first transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone to athyreotic mice as a proof of concept for future therapeutic development. ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| العلاقة: | uri/info:doi/10.1101/2021.12.01.470729; https://dipot.ulb.ac.be/dspace/bitstream/2013/336650/3/2021.12.01.470729v1.full.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/336650Test |
| الإتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/336650Test https://dipot.ulb.ac.be/dspace/bitstream/2013/336650/3/2021.12.01.470729v1.full.pdfTest |
| رقم الانضمام: | edsbas.60CD56F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |