A histone-like motif in yellow fever virus contributes to viral replication
| العنوان: | A histone-like motif in yellow fever virus contributes to viral replication |
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| المؤلفون: | Carolina Adura, Alan Gerber, Alexander Tarakhovsky, Dinshaw J. Patel, Diego Mourao, Benjamin A Garcia, Henrik Molina, Matthew R. Paul, Inmaculada Rioja, Charles M. Rice, Natarajan V. Bhanu, Leticia A.M. Carneiro, Robert G. Roeder, Brian D. Dill, Thomas L. Carroll, Gerard Joberty, Rab K. Prinjha, Shoudeng Chen, Leonia Bozzacco, Uwe Schaefer, Margaret R. MacDonald |
| المساهمون: | Organic Chemistry, AIMMS |
| المصدر: | bioRxiv, 2020. Cold Spring Harbor Laboratory Press Mourao, D, Chen, S, Schaefer, U, Bozzacco, L, Carneiro, L A, Gerber, A, Adura, C, Dill, B D, Molina, H, Carroll, T, Paul, M, Bhanu, N V, Garcia, B A, Joberty, G, Rioja, I, Prinjha, R K, Roeder, R G, Rice, C M, MacDonald, M R, Patel, D J & Tarakhovsky, A 2020, ' A histone-like motif in yellow fever virus contributes to viral replication ', bioRxiv, vol. 2020 . https://doi.org/10.1101/2020.05.05.078782Test |
| بيانات النشر: | Cold Spring Harbor Laboratory Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Regulation of gene expression, biology, viruses, RNA virus, biology.organism_classification, Bromodomain, Cell biology, Chromatin, Histone H4, Histone, Viral replication, SDG 3 - Good Health and Well-being, biology.protein, Host adaptation |
| الوصف: | The mimicry of host proteins by viruses contributes to their ability to suppress antiviral immunity and hijack host biosynthetic machinery1. Host adaptation to evade this exploitation depends on host protein functional redundancy2. Non-redundant, essential host proteins have limited potential to adapt without severe consequences3. Histones, which are essential for genome architecture and control of gene expression, are among the most evolutionary conserved proteins4. Here we show that the capsid protein of the flavivirus yellow fever virus (YFV), mimics histone H4 and interferes with chromatin gene regulation by BRD4, a bromodomain and extraterminal domain (BET) protein. Two acetyl-lysine residues of YFV capsid are embedded in a histone-like motif that interacts with the BRD4 bromodomain, affecting gene expression and influencing YFV replication. These findings reveal histone mimicry as a strategy employed by an RNA virus that replicates in the cytosol5 and define convergent and distinct molecular determinants for motif recognition of the viral mimic versus histone H4. |
| اللغة: | English |
| تدمد: | 2692-8205 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cf35bd9001f77ec669a28d3ab24aa3Test https://research.vu.nl/en/publications/f6715f1a-4a11-4342-a462-0d6a0020ccd0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b8cf35bd9001f77ec669a28d3ab24aa3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26928205 |
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