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1
المؤلفون: Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsubasa Hino, Naoshi Yamamoto, Hiroshi Nagase, Yasuyuki Nagumo, Masashi Yanagisawa, Noriki Kutsumura, Tsuyoshi Saitoh, Ryuji Tanimura
المصدر: Bioorganicmedicinal chemistry letters. 59
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Naphthalenes, Ring (chemistry), Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Orexin Receptors, Amide, Drug Discovery, medicine, Humans, Molecular Biology, Naphthalene, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Orexin receptor, chemistry, Docking (molecular), Drug Design, Benzamides, Molecular Medicine, Pharmacophore, Methyl group
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a156a52c16b33607fe4372900cffff08Test
https://pubmed.ncbi.nlm.nih.gov/35007725Test -
2
المؤلفون: Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
المصدر: Bioorganicmedicinal chemistry letters. 60
مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Tetrahydronaphthalenes, Orexin Receptors, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Humans, Molecular Biology, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aae6454ae5d938fb321fbcadcbfd765Test
https://pubmed.ncbi.nlm.nih.gov/35051577Test -
3
المؤلفون: Kaori Togashi, Kengo Fukui, Yuji Nakamoto, Yoichi Shimizu, Hideo Saji, Hiroyuki Watanabe, Masahiro Ono, Yuki Idoko
المصدر: Bioorganicmedicinal chemistry letters. 29(13)
مصطلحات موضوعية: Biodistribution, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Orexin Receptors, Tetrahydroisoquinolines, Drug Discovery, medicine, Humans, Receptor, Molecular Biology, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Tetrahydroisoquinoline, Organic Chemistry, In vitro, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, Positron emission tomography, THIQ, Biophysics, Molecular Medicine, Preclinical imaging, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc2a38612045c3acbe26f854455dff9Test
https://pubmed.ncbi.nlm.nih.gov/31056243Test -
4
المؤلفون: Masashi Yanagisawa, Naoshi Yamamoto, Daichi Hayakawa, Yasuyuki Nagumo, Masahiro Yata, Yurie Watanabe, Sayaka Ohrui, Yukiko Ishikawa, Takahiro Okada, Noriki Kutsumura, Tsuyoshi Saitoh, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Hiroshi Nagase, Hiroaki Gouda
المصدر: Bioorganicmedicinal chemistry letters. 27(17)
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ring (chemistry), 01 natural sciences, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, Opioid receptor, Orexin Receptors, Drug Discovery, medicine, Side chain, Humans, Receptor, Molecular Biology, Sulfonamides, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Receptor antagonist, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Morphinans, Molecular Medicine, Epoxy Compounds, Orexin Receptor Antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb3aa0619b3252102d1a15a8a11cd02Test
https://pubmed.ncbi.nlm.nih.gov/28739044Test -
5
المؤلفون: Chen Shuhui, Chen Yuan, Changqing Cao, Zhi Luo, Lan Jiong, Hongmei Zhang, Jian Li, Xing Liu, Wei Liang, Haiying He, Shi Weihua, Lijuan Hou, Liang Shen, Wang Yuhe, Qing Xu, Li Yufeng, Hu Yi, Wu Songliang, Lv Qiang, Yu Sun
المصدر: Bioorganicmedicinal chemistry letters. 27(6)
مصطلحات موضوعية: 0301 basic medicine, Male, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, Pharmacokinetics, Sleep Initiation and Maintenance Disorders, Drug Discovery, Potency, Animals, Humans, Pyrroles, Receptor, Molecular Biology, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Suvorexant, Antagonist, Electroencephalography, Orexin receptor, 0104 chemical sciences, Orexin, Rats, 030104 developmental biology, biology.protein, Molecular Medicine, Orexin Receptor Antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366ec88da280a5bc06b6f57d98889a94Test
https://pubmed.ncbi.nlm.nih.gov/28216404Test -
6
المؤلفون: Christopher J. Winrow, John J. Renger, Craig A. Stump, Tamara D. Cabalu, Terrence P. McDonald, C. Meacham Harell, Scott D. Kuduk, Anthony L. Gotter, Julie A. O'Brien, Cooke Andrew John, Paul J. Coleman, Peter D. Williams, Joseph G. Bruno
المصدر: Bioorganicmedicinal chemistry letters. 26(23)
مصطلحات موضوعية: 0301 basic medicine, Filorexant, Imidazopyridine, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Piperidines, Orexin Receptors, Drug Discovery, medicine, Functional selectivity, Animals, Humans, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Suvorexant, Antagonist, Orexin receptor, Orexin, Rats, 030104 developmental biology, Molecular Medicine, Orexin Receptor Antagonists, Rats, Transgenic, 030217 neurology & neurosurgery, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27663ab0b0c341d4ece92fdca73f2a52Test
https://pubmed.ncbi.nlm.nih.gov/27818110Test -
7
المؤلفون: Qi Huang Zheng, Mingzhang Gao, Min Wang
المصدر: Bioorganicmedicinal chemistry letters. 26(15)
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Orexin hypocretin, Pharmaceutical Science, Carboxamide, Ligands, 01 natural sciences, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, Radioligand Assay, Orexin Receptors, Drug Discovery, medicine, Radioligand, Molecule, Humans, Carbon Radioisotopes, Molecular Biology, Reference standards, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Yield (chemistry), Positron-Emission Tomography, Molecular Medicine, Radiopharmaceuticals, Boronic acid, Nuclear chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae45c392845a90aec2ad8bf5a3c6e584Test
https://pubmed.ncbi.nlm.nih.gov/27268698Test -
8
المؤلفون: Jodi T. Williams, Romain Siegrist, Catherine Roch, Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, Emmanuelle Cottreel, Christine Brotschi, John Gatfield, Hamed Aissaoui, Francois Jenck, Bibia Heidmann, Christoph Boss, Alexander Treiber
المصدر: Bioorganicmedicinal chemistry letters. 25(9)
مصطلحات موضوعية: medicine.medical_specialty, Lactams, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Structure-Activity Relationship, Orexin Receptors, Internal medicine, Drug Discovery, medicine, Potency, Animals, Humans, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Orexin Receptor Antagonists, Organic Chemistry, Metabolic stability, Receptor antagonist, Sleep in non-human animals, Orexin receptor, In vitro, Pyrrolidinones, Rats, Endocrinology, Molecular Medicine, Efflux, Sleep
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9286e1662d09e8795778dab3c5a2fb4aTest
https://pubmed.ncbi.nlm.nih.gov/25838147Test -
9
المؤلفون: Swati P. Mercer, Thomayant Prueksaritanont, Donghui Cui, Anthony J. Roecker, Tamara D. Cabalu, Pamela L. Tannenbaum, Jeffrey M. Bergman, Scott D. Kuduk, Christopher J. Winrow, Kevin F. Gilbert, Susan L. Garson, John J. Renger, Paul J. Coleman, Wei Lemaire, Anthony L. Gotter, C. Meacham Harrell, Steven V. Fox
المصدر: Bioorganicmedicinal chemistry letters. 25(21)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Isostere, Clinical Biochemistry, Dual Orexin Receptor Antagonists, Pharmaceutical Science, Doras, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Orexin Receptors, Amide, Sleep Initiation and Maintenance Disorders, Drug Discovery, Quinazoline, Animals, Humans, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Suvorexant, Antagonist, biology.organism_classification, Orexin, Rats, Disease Models, Animal, Pyrimidines, chemistry, Microsomes, Liver, Quinazolines, Molecular Medicine, Orexin Receptor Antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1815e46aa885c080cfcf4688a93084Test
https://pubmed.ncbi.nlm.nih.gov/25613676Test -
10
المؤلفون: Thomayant Prueksaritanont, Susan L. Garson, Tamara D. Cabalu, Wei Lemaire, Anthony L. Gotter, John J. Renger, Donghui Cui, Swati P. Mercer, Anthony J. Roecker, Steven V. Fox, C. Meacham Harrell, Christopher J. Winrow, Paul J. Coleman
المصدر: Bioorganicmedicinal chemistry letters. 24(9)
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Doras, Biochemistry, chemistry.chemical_compound, In vivo, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, Potency, Animals, Humans, Receptor, Molecular Biology, biology, Chemistry, Organic Chemistry, Antagonist, biology.organism_classification, Sleep in non-human animals, Orexin, Rats, Pyrimidines, Diphosgene, Molecular Medicine, Orexin Receptor Antagonists, Sleep
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe91295538ba08887f8b05b93d5869eeTest
https://pubmed.ncbi.nlm.nih.gov/24704030Test