Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity
| العنوان: | Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity |
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| المؤلفون: | Maria Iorizzi, Maurizio Bifulco, Chiara Laezza, Clara Conicella, Virginia Lanzotti, Maria Cammareri, Gabriella Corea |
| المساهمون: | Corea, G., Iorizzi, M., Lanzotti, Virginia, Cammareri, M., Conicella, C., Laezza, C., Bifulco, M. |
| المصدر: | Bioorganic & medicinal chemistry 12 (2004): 4909–4915. doi:10.1016/j.bmc.2004.06.042 info:cnr-pdr/source/autori:Corea G., Iorizzi M., Lanzotti V., Cammareri M., Conicella C., Laezza C., Bifulco M./titolo:Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity/doi:10.1016%2Fj.bmc.2004.06.042/rivista:Bioorganic & medicinal chemistry (Print)/anno:2004/pagina_da:4909/pagina_a:4915/intervallo_pagine:4909–4915/volume:12 |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | antiproliferative activity, Aster sedifolius, triterpene saponins, Stereochemistry, TRITERPENOID SAPONINS, Clinical Biochemistry, Saponin, Disaccharide, Pharmaceutical Science, Pharmacognosy, Asteraceae, Biochemistry, Cell Line, Terpene, chemistry.chemical_compound, Triterpenoid, Triterpene, Drug Discovery, SPECTRA, Thyroid cells, Animals, Oleanolic Acid, Molecular Biology, chemistry.chemical_classification, SPECTROSCOPY, Chemistry, Plant Extracts, Organic Chemistry, Absolute configuration, Glycoside, General Medicine, Plant Components, Aerial, Saponins, Terpenoid, Growth Inhibitors, Rats, Molecular Medicine, Echinocystic acid, Antiproliferative effect, Two-dimensional nuclear magnetic resonance spectroscopy |
| الوصف: | A phytochemical analysis of Aster sedifolius has led to the isolation of three novel triterpenoid saponins, based on an oleane-type skeleton and named astersedifolioside A (1), B (2) and C (3). On the basis of chemical, and 2D NMR and mass spectrometry data, the structures of the new compounds were elucidated as 3-O-[alpha-L-rhamnopyranosyl (I --> 2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-alpha-L-rhamnopyranosyl (I --> 2)-alpha-L-arabinopyranoside] (1), 3-O-[alpha-L-rhamnopyranosyl (1 --> 2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (1 --> 4)-O-alpha-L-rhamnopyranosyl (1 --> 2)-alpha(-L-arabinopyranoside] (2) and 3-O-[alpha-L-rhamnopyranosyl (I --> 2)-beta-D-glucopyranosyl (I --> 2)-alpha-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (I 4)-O-alpha-L-rhamnopyranosyl (I --> 2)-alpha-L-arabinopyranoside] (3). The isolated compounds showed antiproliferative effect in KiMol, a transformed thyroid cell line. (C) 2004 Published by Elsevier Ltd. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 0968-0896 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ab46af3319821146818e1a4a82d943Test https://pubmed.ncbi.nlm.nih.gov/15336270Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f3ab46af3319821146818e1a4a82d943 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09680896 |
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