يعرض 1 - 10 نتائج من 10 نتيجة بحث عن '"Yanagisawa, Masashi"', وقت الاستعلام: 0.87s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

    المؤلفون: Saitoh, Tsuyoshi1 (AUTHOR), Seki, Kazunori1 (AUTHOR), Nakajima, Ryo1 (AUTHOR), Yamamoto, Naoshi1 (AUTHOR), Kutsumura, Noriki1 (AUTHOR), Nagumo, Yasuyuki1 (AUTHOR), Irukayama-Tomobe, Yoko1 (AUTHOR), Ogawa, Yasuhiro1 (AUTHOR), Ishikawa, Yukiko1 (AUTHOR), Tanimura, Ryuji1 (AUTHOR), Yanagisawa, Masashi1 (AUTHOR), Nagase, Hiroshi1 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Sep2019, Vol. 29 Issue 18, p2655-2658. 4p.

    مصطلحات موضوعية: *OREXINS, *CURRICULUM, *SKELETON, *LIGANDS (Biochemistry)


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  2. 2
    دورية أكاديمية
    Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

    المؤلفون: Ohrui, Sayaka1, Yamamoto, Naoshi1, Saitoh, Tsuyoshi1, Kutsumura, Noriki1, Nagumo, Yasuyuki1, Irukayama-Tomobe, Yoko1, Ogawa, Yasuhiro1, Ishikawa, Yukiko1, Watanabe, Yurie2, Hayakawa, Daichi2, Gouda, Hiroaki2, Yanagisawa, Masashi1, Nagase, Hiroshi1 nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Feb2018, Vol. 28 Issue 4, p774-777. 4p.

    مصطلحات موضوعية: *OREXINS, *CHEMICAL derivatives, *SUBSTITUENTS (Chemistry), *DEHYDRATION reactions, *CONFORMATIONAL analysis


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  3. 3
    دورية أكاديمية
    Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

    المؤلفون: Yamamoto, Naoshi1, Ohrui, Sayaka1, Okada, Takahiro2, Yata, Masahiro2, Saitoh, Tsuyoshi1, Kutsumura, Noriki1, Nagumo, Yasuyuki1, Irukayama-Tomobe, Yoko1, Ogawa, Yasuhiro1, Ishikawa, Yukiko1, Watanabe, Yurie3, Hayakawa, Daichi3, Gouda, Hiroaki3, Yanagisawa, Masashi1, Nagase, Hiroshi1,2 nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Sep2017, Vol. 27 Issue 17, p4176-4179. 4p.

    مصطلحات موضوعية: *OREXINS, *SULFONAMIDES, *CONFORMATIONAL analysis, *PHARMACEUTICAL chemistry, *OPIOID receptors


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  4. 4
    دورية أكاديمية
    Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton.

    المؤلفون: Amezawa, Mao1 (AUTHOR), Yamamoto, Naoshi2 (AUTHOR), Nagumo, Yasuyuki2 (AUTHOR), Kutsumura, Noriki1,2,3 (AUTHOR), Ishikawa, Yukiko2 (AUTHOR), Yanagisawa, Masashi2,4,5 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp, Saitoh, Tsuyoshi1,2,3 (AUTHOR) saito.tsuyoshi.gf@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Feb2023, Vol. 82, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *ASYMMETRIC synthesis, *SKELETON, *STEREOISOMERS, *STEREOCHEMISTRY, *CARBAMATES, *HUMAN skeleton, *ENTORHINAL cortex


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  5. 5
    دورية أكاديمية
    Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.

    المؤلفون: Iio, Keita1 (AUTHOR), Saitoh, Tsuyoshi1,2 (AUTHOR), Ohshita, Ryuichiro1 (AUTHOR), Hino, Tsubasa1 (AUTHOR), Amezawa, Mao1 (AUTHOR), Takayama, Yoshiaki1 (AUTHOR), Nagumo, Yasuyuki2 (AUTHOR), Yamamoto, Naoshi2 (AUTHOR), Kutsumura, Noriki1,2 (AUTHOR), Irukayama-Tomobe, Yoko2 (AUTHOR), Ishikawa, Yukiko2 (AUTHOR), Tanimura, Ryuji3 (AUTHOR), Yanagisawa, Masashi2,4,5 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Mar2022, Vol. 60, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *OREXINS, *CHIRALITY, *ASYMMETRIC synthesis, *STEREOCHEMISTRY, *SKELETON, *ACETAMIDE


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  6. 6
    دورية أكاديمية
    Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives.

    المؤلفون: Katoh, Koki1 (AUTHOR), Kutsumura, Noriki1,2 (AUTHOR), Yamamoto, Naoshi2 (AUTHOR), Nagumo, Yasuyuki2 (AUTHOR), Saitoh, Tsuyoshi2 (AUTHOR), Ishikawa, Yukiko2 (AUTHOR), Irukayama-Tomobe, Yoko2 (AUTHOR), Tanimura, Ryuji3 (AUTHOR), Yanagisawa, Masashi2,4,5 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Mar2022, Vol. 59, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *CONFORMATIONAL analysis, *OPIOID receptors, *HYDROGEN bonding


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  7. 7
    دورية أكاديمية
    Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.

    المؤلفون: Hino, Tsubasa1 (AUTHOR), Saitoh, Tsuyoshi1,2 (AUTHOR), Nagumo, Yasuyuki2 (AUTHOR), Yamamoto, Naoshi2 (AUTHOR), Kutsumura, Noriki1,2 (AUTHOR), Irukayama-Tomobe, Yoko2 (AUTHOR), Ishikawa, Yukiko2 (AUTHOR), Tanimura, Ryuji3 (AUTHOR), Yanagisawa, Masashi2,4,5 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Mar2022, Vol. 59, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *NAPHTHALENE, *NAPHTHALENE derivatives, *CONFORMATIONAL analysis, *METHYL groups, *STRUCTURE-activity relationships, *SKELETON, *OREXINS


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  8. 8
    دورية أكاديمية
    Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.

    المؤلفون: Katoh, Koki1 (AUTHOR), Yamamoto, Naoshi1,2 (AUTHOR), Ishikawa, Yukiko2 (AUTHOR), Irukayama-Tomobe, Yoko2 (AUTHOR), Tanimura, Ryuji3 (AUTHOR), Saitoh, Tsuyoshi2 (AUTHOR), Nagumo, Yasuyuki2 (AUTHOR), Kutsumura, Noriki1,2 (AUTHOR), Yanagisawa, Masashi2,4,5 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Mar2022, Vol. 59, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *OPIOID receptors, *AFFINITY groups, *CONFORMATIONAL analysis, *HYDROGEN bonding, *SOCIAL interaction, *STRUCTURE-activity relationships


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  9. 9
    دورية أكاديمية
    Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.

    المؤلفون: Nagumo, Yasuyuki1 (AUTHOR), Katoh, Koki2 (AUTHOR), Iio, Keita2 (AUTHOR), Saitoh, Tsuyoshi1 (AUTHOR), Kutsumura, Noriki1,2 (AUTHOR), Yamamoto, Naoshi1 (AUTHOR), Ishikawa, Yukiko1 (AUTHOR), Irukayama-Tomobe, Yoko1 (AUTHOR), Ogawa, Yasuhiro1 (AUTHOR), Baba, Takeshi3 (AUTHOR), Tanimura, Ryuji3 (AUTHOR), Yanagisawa, Masashi1,4,5 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Sep2020, Vol. 30 Issue 17, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *AVERSION, *ELECTRON pairs, *NONBONDING electron pairs, *OREXINS, *OPIOID receptors, *KNOCKOUT mice, *HYDROGEN bonding


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  10. 10
    دورية أكاديمية
    Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.

    المؤلفون: Saitoh, Tsuyoshi1 (AUTHOR), Seki, Kazunori1,2 (AUTHOR), Nakajima, Ryo1,2 (AUTHOR), Yamamoto, Naoshi1 (AUTHOR), Kutsumura, Noriki1 (AUTHOR), Nagumo, Yasuyuki1 (AUTHOR), Irukayama-Tomobe, Yoko1 (AUTHOR), Ogawa, Yasuhiro1 (AUTHOR), Ishikawa, Yukiko1 (AUTHOR), Yanagisawa, Masashi1,3,4 (AUTHOR), Nagase, Hiroshi1,2 (AUTHOR) nagase.hiroshi.gt@u.tsukuba.ac.jp

    المصدر: Bioorganic & Medicinal Chemistry Letters. Feb2020, Vol. 30 Issue 3, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *STRUCTURE-activity relationships, *OREXINS, *AMINO group, *SUBSTANCE P receptors, *CURRICULUM


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