التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor. |
| المؤلفون: |
Wu, Hao1 (AUTHOR), Liu, Binkai1 (AUTHOR), Yang, Ka1 (AUTHOR), Winston-McPherson, Gabrielle N.1 (AUTHOR), Leisten, Eric D.1 (AUTHOR), Vezina, Chad M.2,3 (AUTHOR), Ricke, William A.3,4 (AUTHOR), Peterson, Richard E.1 (AUTHOR), Tang, Weiping1,5 (AUTHOR) weiping.tang@wisc.edu |
| المصدر: |
Bioorganic & Medicinal Chemistry Letters. Mar2020, Vol. 30 Issue 5, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*ARYL hydrocarbon receptors, *BIOSYNTHESIS, *CARBAZOLE, *TRANSCRIPTION factors, *STRUCTURE-activity relationships, *CELL differentiation |
| مستخلص: |
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6-formylindolo (3,2- b) carbazole (FICZ, 2), a series of analogues has been designed, synthesized and evaluated by cell-based assays. The structure-activity relationships study has successfully led to the discovery of compound 11e with extremely potent activity. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
