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1
المؤلفون: Arndt Meyer, Murali Chebrolu, Christine E. Gee, Grit Laue, Markus Fendt, Laura H. Jacobson, Sangamesh Badiger, Samuel Hintermann, Chetan Pandit, Simona Cotesta, Claudia Betschart, Daniel Hoyer, Vinod D. Chaudhari, Dirk Behnke, Trixie Wagner
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5555-5560
مصطلحات موضوعية: Pyridines, High-throughput screening, Clinical Biochemistry, Dual Orexin Receptor Antagonists, Administration, Oral, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Doras, Biochemistry, Mice, Drug Discovery, Animals, Molecular Biology, G protein-coupled receptor, Molecular Structure, biology, Chemistry, Drug discovery, Orexin Receptor Antagonists, Organic Chemistry, biology.organism_classification, Orexin, Pyrazoles, Molecular Medicine, Administration, Intravenous, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683f840d5741ac67440ee89e98efc728Test
https://doi.org/10.1016/j.bmcl.2015.10.055Test -
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المؤلفون: Christoph Boss, Catherine Roch
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:2875-2887
مصطلحات موضوعية: Sleep Wake Disorders, Lateral hypothalamus, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Neuropeptide, Anxiety, Pharmacology, Biochemistry, Orexin Receptors, mental disorders, Drug Discovery, medicine, Animals, Humans, Wakefulness, Molecular Biology, media_common, Orexins, Chemistry, Addiction, digestive, oral, and skin physiology, Organic Chemistry, Brain, Panic, Orexin receptor, Orexin, nervous system, Hypothalamus, Molecular Medicine, medicine.symptom, Sleep, Neuroscience, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5819d7b04952b0bf49704aac7a7502Test
https://doi.org/10.1016/j.bmcl.2015.05.012Test -
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المؤلفون: Christina N. DiMarco, Anthony L. Gotter, Alan T. Savitz, Joanne Stevens, Joseph G. Bruno, Tamara D. Cabalu, John J. Renger, Jason W. Skudlarek, Pamela L. Tannenbaum, Paul J. Coleman, Scott D. Kuduk, Joseph Brunner, Susan L. Garson, Christopher J. Winrow, Julie A. O'Brien, Charles M. Harrell, Mark H. Pausch
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:2488-2492
مصطلحات موضوعية: Filorexant, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Orexin Receptors, Sleep Initiation and Maintenance Disorders, mental disorders, Drug Discovery, medicine, Animals, Benzamide, Molecular Biology, G protein-coupled receptor, Organic Chemistry, Antagonist, Triazoles, Receptor antagonist, Orexin receptor, Rats, Orexin, Pyrimidines, chemistry, Molecular Medicine, Orexin Receptor Antagonists, Antagonism, Half-Life, Protein Binding, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acadb1d22021c26105aca8a6acbc634Test
https://doi.org/10.1016/j.bmcl.2015.04.066Test -
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المؤلفون: John J. Renger, Joyce Stellabott, Swati P. Mercer, Wei Lemaire, Thomas S. Reger, Christopher D. Cox, Pamela L. Tannenbaum, Christopher J. Winrow, Joanne Stevens, Donghui Cui, Joseph G. Bruno, Susan L. Garson, Rowena V. Cube, M. Christa Mattern, Dansu Li, C. Meacham Harrell, Paul J. Coleman, John D. Schreier, Tamara D. Cabalu, George D. Hartman, Anthony L. Gotter, Steven V. Fox, Jeffrey M. Bergman, Anthony J. Roecker, Thomayant Prueksaritanont, Steven D. Young
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:4884-4890
مصطلحات موضوعية: medicine.medical_specialty, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Doras, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Sleep Initiation and Maintenance Disorders, Internal medicine, mental disorders, Drug Discovery, medicine, Animals, Humans, Isonicotinamide, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, CYP3A4, Organic Chemistry, Antagonist, biology.organism_classification, Small molecule, Orexin receptor, Rats, Orexin, Thiazoles, Endocrinology, chemistry, Molecular Medicine, Orexin Receptor Antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9311b64883bbbf0739f9c64c3873b7ceTest
https://doi.org/10.1016/j.bmcl.2014.08.041Test -
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المؤلفون: Pamela L. Tannenbaum, Scott D. Kuduk, Tamara D. Cabalu, Joseph Brunner, Mark A. Pausch, Christina N. Di Marco, Joseph G. Bruno, Paul J. Coleman, Anthony L. Gotter, John J. Renger, Joanne Stevens, Jason W. Skudlarek, Christopher J. Winrow, Julie A. O'Brien
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:1784-1789
مصطلحات موضوعية: Filorexant, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Orexin Receptors, In vivo, Drug Discovery, medicine, Animals, Potency, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, Acetylene, Organic Chemistry, Antagonist, In vitro, Orexin receptor, Orexin, Pyrimidines, chemistry, Molecular Medicine, Orexin Receptor Antagonists, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f9a6d949d1dc719f00a34c6b92861fTest
https://doi.org/10.1016/j.bmcl.2014.02.026Test -
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المؤلفون: Audrey Chardonneau, Thierry Sifferlen, John Gatfield, Hamed Aissaoui, Alexander Treiber, Jodi T. Williams, Francois Jenck, Christine Brotschi, Johannes Hoecker, Bibia Heidmann, Christoph Boss, Romain Siegrist, Emmanuelle Cottreel, Catherine Brisbare-Roch, Amandine Boller
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:1201-1208
مصطلحات موضوعية: Dose-Response Relationship, Drug, Lactams, Molecular Structure, Chemistry, Organic Chemistry, Clinical Biochemistry, Dual Orexin Receptor Antagonists, Pharmaceutical Science, Pharmacology, Metabolic stability, Biochemistry, Rats, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Animals, Humans, Molecular Medicine, Structure–activity relationship, Potency, Orexin Receptor Antagonists, Rats, Wistar, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35567abd068fe7a262e99b0bc0448cedTest
https://doi.org/10.1016/j.bmcl.2013.12.092Test -
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المؤلفون: Ornella Letari, Benedetta Buzzi, Paolo Garofalo, Luigi Piero Stasi, Luca Canciani, Gianfranco Caselli, Fabrizio Colace, Roberto Artusi, Matteo Salvi, Clara Bovino, Patrice Larger, Stefano Mandelli, Lorenzo Perugini, Silvia Giambuzzi, Sabrina Pucci, PierLuigi Toro
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2653-2658
مصطلحات موضوعية: Receptors, Neuropeptide, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Heptanes, Receptors, G-Protein-Coupled, Structure-Activity Relationship, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Orexin Receptors, mental disorders, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Spiro Compounds, Receptor, Molecular Biology, Aza Compounds, biology, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Brain, Cytochrome P450, Rats, Orexin, Bioavailability, nervous system, chemistry, biology.protein, Molecular Medicine, Piperidine, Selectivity, Lead compound, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f102f2b13ddd11878c94ed47b63421Test
https://doi.org/10.1016/j.bmcl.2013.02.093Test -
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المؤلفون: Anthony Smith, Li Lin, Theodore M. Kamenecka, Patricia McDonald, Purva Bali, Michael D. Cameron, Xinyi Song, Rong Jiang, Claudia Ruiz Bayona, Paul J. Kenny
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3890-3894
مصطلحات موضوعية: Receptors, Neuropeptide, Drug, Substance-Related Disorders, Stereochemistry, media_common.quotation_subject, Clinical Biochemistry, Orexin hypocretin, Pharmaceutical Science, Pharmacology, Biochemistry, Article, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Orexin Receptors, In vivo, mental disorders, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, Molecular Biology, media_common, G protein-coupled receptor, Molecular Structure, Chemistry, Organic Chemistry, Brain, Rats, Orexin, Liver, Microsomes, Liver, Molecular Medicine, Piperidine, Antipsychotic Agents
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b712d7524fa2031a633c951c2eca3faTest
https://doi.org/10.1016/j.bmcl.2012.04.122Test -
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المؤلفون: Yoshihide Tomata, Mariko Hirozane, Tatsuhiko Fujimoto, Jun Kunitomo, Shogo Marui
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6409-6413
مصطلحات موضوعية: Receptors, Neuropeptide, Chemistry, Drug discovery, digestive, oral, and skin physiology, Organic Chemistry, Clinical Biochemistry, Orexin hypocretin, Pharmaceutical Science, Pharmacology, Ligands, Biochemistry, Orexin receptor, Receptors, G-Protein-Coupled, Piperidines, nervous system, Orexin Receptors, mental disorders, Drug Discovery, Molecular Medicine, Receptor, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15888cd18d06049c027d291b9ffbd7f5Test
https://doi.org/10.1016/j.bmcl.2011.08.094Test -
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المؤلفون: Thomayant Prueksaritanont, Christopher J. Winrow, Duane R. Reiss, Georgia B. McGaughey, John J. Renger, Christopher D. Cox, George D. Hartman, Paul J. Coleman, C. Meacham Harrell, Richard G. Ball, John D. Schreier, Michael J. Bogusky
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2311-2315
مصطلحات موضوعية: Models, Molecular, Receptors, Neuropeptide, Sleep Wake Disorders, Clinical Biochemistry, Solid-state, Pharmaceutical Science, Neuropeptide, Pharmacology, Crystallography, X-Ray, Biochemistry, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Dogs, Orexin Receptors, mental disorders, Drug Discovery, Animals, Humans, Receptor, Molecular Biology, Chemistry, Orexin Receptor Antagonists, digestive, oral, and skin physiology, Organic Chemistry, Azepines, Small molecule, Orexin receptor, Rats, Sprague dawley, nervous system, Molecular Medicine, Wakefulness, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db9e3e6baa9eb7cafd4bb29a45f3a1eTest
https://doi.org/10.1016/j.bmcl.2010.01.138Test