التفاصيل البيبلوغرافية
| العنوان: |
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities |
| المؤلفون: |
Tang, Haifeng haifeng_tang@merck.com, Yan, Yan1, Feng, Zhe1, de Jesus, Reynalda K.1, Yang, Lihu1, Levorse, Dorothy A.1, Owens, Karen A.1, Akiyama, Taro E.1, Bergeron, Raynald1, Castriota, Gino A.1, Doebber, Thomas W.1, Ellsworth, Kenneth P.1, Lassman, Michael E.1, Li, Cai1, Wu, Margaret S.1, Zhang, Bei B.1, Chapman, Kevin T.1, Mills, Sander G.1, Berger, Joel P.1, Pasternak, Alexander1 |
| المصدر: |
Bioorganic & Medicinal Chemistry Letters. Oct2010, Vol. 20 Issue 20, p6088-6092. 5p. |
| مصطلحات موضوعية: |
*DRUG development, *DRUG design, *ENZYME inhibitors, *HYPOGLYCEMIC agents, *LABORATORY mice, *FATTY acids, *OXIDATION, *ACETYLCOENZYME A, *OBESITY treatment |
| مستخلص: |
Abstract: A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
Academic Search Index |
