نتائج البحث - "Non-Receptor Type 1"

1

BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity

المؤلفون: Lijuan Wu, Chuan-Liang Zhang, Lu Xiao, Shu-Lin Wang, Xiaochun Liu

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:244-247

مصطلحات موضوعية: Stereochemistry, Glucose uptake, Clinical Biochemistry, Drug Evaluation, Preclinical, Palmitic Acid, Pharmaceutical Science, Peptide, Conjugated system, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, Palmitic acid, Structure-Activity Relationship, chemistry.chemical_compound, Insulin resistance, Drug Discovery, medicine, Humans, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Bh3 mimetics, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Hep G2 Cells, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, biological phenomena, cell phenomena, and immunity, Peptides, Selectivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d85e8c0924b519ed1510d0a688e530bTest
https://doi.org/10.1016/j.bmcl.2018.11.047Test

2

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

المؤلفون: Alexandra Naß, Paolo De Paoli, Mario Cappiello, Rosanna Maccari, Francesco Balestri, Gerhard Wolber, Antonella Del Corso, Giulia Lori, Ilenia Adornato, Rosaria Ottanà

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3712-3720

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, 4-Thiazolidinone derivatives, Aldose reductase, Designed multiple ligands, Diabetes mellitus, Protein tyrosine phosphatase 1B, Biochemistry, Molecular Medicine, Molecular Biology, 3003, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Pharmaceutical Science, 4-Thiazolidinone derivatives, Aldose reductase, Designed multiple ligands, Diabetes mellitus, Protein tyrosine phosphatase 1B, Biochemistry, Molecular Medicine, Molecular Biology 3003, Drug Discovery 3003 Pharmaceutical Science, Clinical Biochemistry, Organic Chemistry, Pharmacology, Ligands, Inhibitory postsynaptic potential, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Aldehyde Reductase, Drug Discovery, medicine, Humans, Hypoglycemic Agents, Enzyme Inhibitors, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Type 2 Diabetes Mellitus, medicine.disease, Protein Tyrosine Phosphatase 1B, In vitro, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Diabetes Mellitus, Type 2, 4-thiazolidinone, Thiazolidines

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6073126821f647fa6752075bff55109aTest
https://doi.org/10.1016/j.bmcl.2018.10.024Test

3

Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase

المؤلفون: Hayato Tsuge, Ryuji Uchida, Hiroyuki Yamazaki, Ohgi Takahashi

المصدر: Bioorganic & Medicinal Chemistry Letters. 53:128422

مصطلحات موضوعية: Circular dichroism, Stereochemistry, Eupatorium, Clinical Biochemistry, Pharmaceutical Science, Protein tyrosine phosphatase, Sesquiterpene, Sesquiterpene lactone, Biochemistry, Sesquiterpenes, Germacrane, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, IC50, Inhibitory effect, Density Functional Theory, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, Eupatorium chinense, biology.organism_classification, Plant Leaves, chemistry, Molecular Medicine, Two-dimensional nuclear magnetic resonance spectroscopy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e7ae5f8a280f4b430306353476f344Test
https://doi.org/10.1016/j.bmcl.2021.128422Test

4

PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation

المؤلفون: Jinwoong Kim, Thi Kim Quy Ha, Jun Li Yang, Ba-Wool Lee, Won Keun Oh

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:5076-5081

مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, Glucose uptake, Clinical Biochemistry, Insulins, Molecular Conformation, Iris, Pharmaceutical Science, AMP-Activated Protein Kinases, 01 natural sciences, Biochemistry, Cell Line, Mice, 03 medical and health sciences, AMP-activated protein kinase, Drug Discovery, Animals, Enzyme Inhibitors, Phosphorylation, Molecular Biology, IC50, Mitogen-Activated Protein Kinase 1, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Biological Products, Binding Sites, Mitogen-Activated Protein Kinase 3, biology, Plant Extracts, 010405 organic chemistry, Chemistry, Organic Chemistry, Acetyl-CoA carboxylase, AMPK, Iris sanguinea, Protein Structure, Tertiary, 0104 chemical sciences, Molecular Docking Simulation, Glucose, 030104 developmental biology, Seeds, biology.protein, Molecular Medicine, Signal transduction, Acetyl-CoA Carboxylase, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759a9e4d368900c2aee369f324c93f62Test
https://doi.org/10.1016/j.bmcl.2017.09.031Test

5

Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity

المؤلفون: G.R. Vanaja, Srinivas Endoori, Srinu Bodige, Kali Charan Gulipalli, Nareshvarma Seelam, J. N. Narendra Sharath Chandra, G. Suresh Babu, Parameshwar Ravula

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3558-3564

مصطلحات موضوعية: 0301 basic medicine, Cell Survival, In silico, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Thiophenes, Protein tyrosine phosphatase, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Neoplasms, Drug Discovery, Humans, Computer Simulation, MTT assay, Enzyme Inhibitors, Tyrosine, Molecular Biology, IC50, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Hep G2 Cells, In vitro, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Drug Design, MCF-7 Cells, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb3e6a1da3e3c49dca81a0a017523e2Test
https://doi.org/10.1016/j.bmcl.2017.05.047Test

6

Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction

المؤلفون: Li-Xin Gao, Tong Zhu, Shikun Jia, Wenhao Hu, Suzhen Dong, Shunying Liu, Yubing Lei, Jia Li

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1105-1108

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7799759ae41606f52a604f4c751a8dc3Test
https://doi.org/10.1016/j.bmcl.2016.11.055Test

7

Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking

المؤلفون: Monika Saini, Ashok Kumar, Anudeep Kumar Narula, Sudha Jain, Chandra S. Azad, Mohammad Faheem Khan

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:1988-1992

مصطلحات موضوعية: animal structures, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Protein tyrosine phosphatase, Inhibitory postsynaptic potential, environment and public health, 01 natural sciences, Biochemistry, Molecular Docking Simulation, Cell Line, Structure-Activity Relationship, Insulin resistance, Drug Discovery, medicine, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, IC50, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, medicine.disease, Recombinant Proteins, 0104 chemical sciences, enzymes and coenzymes (carbohydrates), 010404 medicinal & biomolecular chemistry, Insulin receptor, Cell culture, Drug Design, biology.protein, Molecular Medicine, Diterpenes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0fc0e3dcf325a05c59ab75a71341d8Test
https://doi.org/10.1016/j.bmcl.2016.03.003Test

8

Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity

المؤلفون: Jing-Xu Gong, Jia Li, Yue-Wei Guo, Cheng-Shi Jiang, Xu-Wen Li, Li-Xin Gao, Zhong-Hua Wang, Jing-Ya Li, Li Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:778-781

مصطلحات موضوعية: Phidianidine B, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, Molecular Docking Simulation, Indole Alkaloids, Inhibitory Concentration 50, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Humans, Structure–activity relationship, Enzyme Inhibitors, Binding site, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Oxadiazoles, Binding Sites, 010405 organic chemistry, Chemistry, Organic Chemistry, Combinatorial chemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, Selectivity, hormones, hormone substitutes, and hormone antagonists, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e62109f40cba27d53e0dac17785e0c3Test
https://doi.org/10.1016/j.bmcl.2015.12.097Test

9

Novel PTP1B inhibitors identified by DNA display of fragment pairs

المؤلفون: Mihai Ciobanu, Jean-Pierre Daguer, Pierre Morieux, Claudio Zambaldo, Nicolas Winssinger, Sofia Barluenga, Heraklidia A. Ioannidou

المصدر: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 3 (2016) pp. 1080-1085
Bioorganic {&} Medicinal Chemistry Letters

مصطلحات موضوعية: Peptide Nucleic Acids, Microarray, Clinical Biochemistry, Phosphatase, Fragment-based lead discovery, Fragment based drug discovery, Pharmaceutical Science, 010402 general chemistry, 01 natural sciences, Biochemistry, Small Molecule Libraries, chemistry.chemical_compound, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, 010405 organic chemistry, Fragment (computer graphics), Organic Chemistry, DNA-encoded library, PTP1B, DNA, Peptide nucleic acid (PNA), Microarray Analysis, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, Enzyme, chemistry, ddc:540, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733c10ab98821bf0d29e3719fc59196dTest
https://doi.org/10.1016/j.bmcl.2015.11.102Test

10

Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis

المؤلفون: Xue Fei Tan, Ki Hun Park, Yan Wang, Yeong Hun Song, Marcus J. Curtis-Long, Jeong Yoon Kim, Dae Wook Kim, Heung Joo Yuk

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:318-321

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b527105124735c0fb55389926b89c6Test
https://doi.org/10.1016/j.bmcl.2015.12.021Test

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