التفاصيل البيبلوغرافية
العنوان:
Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds
المؤلفون:
Mohindra Seepersaud , Yousef Al-Abed , Larisa Dubrovsky , Michael Bukrinsky , Bela P. Ruzsicska
المصدر:
Bioorganic & Medicinal Chemistry Letters . 12:3117-3119
بيانات النشر:
Elsevier BV, 2002.
سنة النشر:
2002
مصطلحات موضوعية:
Ketone , Anti-HIV Agents , Stereochemistry , Clinical Biochemistry , Active Transport, Cell Nucleus , Pharmaceutical Science , Biochemistry , Chemical synthesis , Structure-Activity Relationship , chemistry.chemical_compound , Drug Discovery , Humans , Molecular Biology , Cells, Cultured , Schiff Bases , Cell Nucleus , chemistry.chemical_classification , Schiff base , Reverse Transcriptase Polymerase Chain Reaction , Macrophages , Organic Chemistry , Arylene , Aromatic amine , Ketones , Pyrimidines , Dicarboxylic acid , chemistry , HIV-1 , Molecular Medicine , Indicators and Reagents , Nuclear transport , Nuclear localization sequence
الوصف:
Arylene bis(methylketone) compounds specifically block nuclear translocation of the HIV-1 pre-integration complex by forming Schiff-base adducts with contiguous lysines within nuclear localization signal.
تدمد:
0960-894X
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc9adb63fce25060c177b7951dde8eaTest https://doi.org/10.1016/s0960-894xTest (02)00642-x
حقوق:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....3dc9adb63fce25060c177b7951dde8ea
قاعدة البيانات:
OpenAIRE
