دورية
Participation of the conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide
| العنوان: | Participation of the conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide |
|---|---|
| المؤلفون: | Murakami, Nobutoshi, Sugimoto, Masanori, Nakajima, Tatsuo, Kawanishi, Motoyuki, Tsutsui, Yasuhiro, Kobayashi, Motomasa |
| المصدر: | Bioorganic & Medicinal Chemistry; November 2000, Vol. 8 Issue: 11 p2651-2661, 11p |
| مستخلص: | 5-epi, 10-epi, 8-Deethyl, and 10-demethyl analogues of callystatin A, a potent cytotoxic spongean polyketide, were synthesized to elucidate structure-requirement for cytotoxic potency. Inversion of the asymmetric center at C-10 in callystatin A minimally affected the activity, while lack of the 10-methyl group in callystatin A decreased cytotoxicity. In addition, the C-5 epimer and the 8-deethyl analogue of callystatin A showed weaker cytotoxicity. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 09680896 14643391 |
|---|---|
| DOI: | 10.1016/S0968-0896(00)00199-1 |