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المؤلفون: Jonas Kaindl, Peter Gmeiner, Harald Hübner, Tobias Schwalbe
المصدر: Bioorganic & Medicinal Chemistry. 25:5084-5094
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Irreversible binding, Mutant, Pharmaceutical Science, Ligands, Biochemistry, Radioligand Assay, 03 medical and health sciences, Dopamine, Dopamine receptor D2, Drug Discovery, Haloperidol, medicine, Radioligand, Humans, Point Mutation, Receptor, Molecular Biology, Receptors, Dopamine D2, Chemistry, Organic Chemistry, Molecular Docking Simulation, Dopamine D2 Receptor Antagonists, 030104 developmental biology, Covalent bond, Schizophrenia, Molecular Medicine, Antipsychotic Agents, Protein Binding, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af42ced8a593b66f9349ad779fae1358Test
https://doi.org/10.1016/j.bmc.2017.06.034Test -
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المؤلفون: Hongmei Jia, Yiyun Huang, Jiale Tian, Fang Xie, Tao Wang, Peter Brust, Winnie Deuther-Conrad, Yingfang He, Jinming Zhang, Hualong Fu, Xiaojun Zhang, Ying Zhang
المصدر: Bioorganic & Medicinal Chemistry 28(2020)14, 115560
مصطلحات موضوعية: Male, Fluorine Radioisotopes, Biodistribution, positron emission tomography, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 1,5-dioxa-9-azaspiro[5.5]undecane derivatives, Decane, σ1 receptor, Ligands, 01 natural sciences, Biochemistry, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Radioligand, Animals, Receptors, sigma, Spiro Compounds, Tissue Distribution, Receptor, 1-oxa-8-azaspiro[4.5]decane derivatives, Molecular Biology, Aza Compounds, Mice, Inbred ICR, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Brain, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, fluorine-18, Molecular Medicine, Undecane, Selectivity, Lead compound, Ex vivo
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed409042f83c0f97f5c361e6d8168c0aTest
https://doi.org/10.1016/j.bmc.2020.115560Test -
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المؤلفون: Lu-Lu Bu, Deyong Ye, Yong Chu, Wen-Bo Yu, Xin Lin, Yan Shen, Xiuhong Lu, Jian Wang, Yan-Fei Chen, Bian Jiang, Peng Zhang
المصدر: Bioorganic & Medicinal Chemistry. 28:115358
مصطلحات موضوعية: Evaluation system, animal diseases, Clinical Biochemistry, Pharmaceutical Science, Ligands, Fibril, Biochemistry, Radioligand Assay, chemistry.chemical_compound, Drug Discovery, Humans, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Brain, dBc, Pet imaging, Combinatorial chemistry, nervous system diseases, Biomarker (cell), nervous system, Design synthesis, Cinnamates, Drug Design, Positron-Emission Tomography, alpha-Synuclein, Molecular Medicine, α synuclein, Lead compound
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466df613570af024ae29cb7cd5d4a949Test
https://doi.org/10.1016/j.bmc.2020.115358Test -
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المؤلفون: Annelien J.M. Zweemer, Christina Weiss, Michael Koch, Anna Junker, Ann Kathrin Strunz, Bernhard Wünsch, Dirk Schepmann, Laura H. Heitman
المصدر: Bioorganic & Medicinal Chemistry, 23(14), 4034-4049
مصطلحات موضوعية: CCR2, Chemokine, Arrestins, Receptors, CCR2, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Chemistry Techniques, Synthetic, Biochemistry, Cell Line, Iodine Radioisotopes, Inhibitory Concentration 50, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Aminolysis, Drug Discovery, Radioligand, Humans, Spiro Compounds, Receptor, Molecular Biology, beta-Arrestins, Trifluoromethyl, biology, Organic Chemistry, Acetal, Appel reaction, chemistry, biology.protein, Molecular Medicine, Calcium
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48055012558f6e3851c442c81f706f5Test
https://doi.org/10.1016/j.bmc.2015.02.019Test -
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المؤلفون: Ashwini K. Banala, Martin H. Moore, Rana Rais, Barbara S. Slusher, Rachel D. Slack, Amy Hauck Newman, Caitlin Burzynski, Jeffrey R. Deschamps, Oluyomi M. Okunola-Bakare, Thomas M. Keck, Alessandro Bonifazi
المصدر: Bioorganic & Medicinal Chemistry. 23:4000-4012
مصطلحات موضوعية: 1,2,3-Triazole, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Phenylpiperazine, Crystallography, X-Ray, Ligands, Biochemistry, Article, Small Molecule Libraries, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Drug Stability, Dopamine receptor D3, Drug Discovery, Animals, Humans, Moiety, Structure–activity relationship, Molecular Biology, Organic Chemistry, Receptors, Dopamine D3, Triazoles, HEK293 Cells, chemistry, Inactivation, Metabolic, Microsomes, Liver, Click chemistry, Molecular Medicine, Click Chemistry, Pharmacophore, Linker
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81a04d310bf91ce40921b649007718cTest
https://doi.org/10.1016/j.bmc.2015.01.017Test -
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المؤلفون: Yiyun Huang, Winnie Deuther-Conrad, Xiaojun Zhang, Xia Wang, Yan Li, Boli Liu, Jiajun Ye, Joerg Steinbach, Peter Brust, Yuanyuan Chen, Jinming Zhang, Hongmei Jia, Mengchao Cui
المصدر: Bioorganic & Medicinal Chemistry. 22:5270-5278
مصطلحات موضوعية: Male, Fluorine Radioisotopes, Biodistribution, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Binding, Competitive, Biochemistry, Rats, Sprague-Dawley, Mice, Radioligand Assay, chemistry.chemical_compound, Piperidines, Drug Discovery, Animals, Humans, Receptors, sigma, Spiro Compounds, Receptor, Molecular Biology, Mice, Inbred ICR, Molecular Structure, Ligand, Chemistry, Organic Chemistry, Brain, Imaging agent, Molecular Imaging, Rats, Positron-Emission Tomography, Autoradiography, Molecular Medicine, Specific activity, Piperidine, Radiopharmaceuticals, Selectivity, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e99ddb75cba9b43d531d25a00278ccTest
https://doi.org/10.1016/j.bmc.2014.08.003Test -
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المؤلفون: Kohei Yamada, Kota Tomaya, Kazuki Deguchi, Kazuki Endo, Hirokazu Matsunaga
المصدر: Bioorganic & Medicinal Chemistry. 22:3072-3082
مصطلحات موضوعية: Male, Agonist, Receptor, Adenosine A2A, medicine.drug_class, Stereochemistry, Vasodilator Agents, Clinical Biochemistry, Pharmaceutical Science, Adenosine receptor antagonist, Biochemistry, Antiparkinson Agents, Rats, Sprague-Dawley, Mice, Radioligand Assay, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Moiety, Structure–activity relationship, Rats, Wistar, Molecular Biology, Catalepsy, Chemistry, Adenine, Organic Chemistry, Antagonist, Parkinson Disease, Adenosine receptor, Adenosine A2 Receptor Antagonists, Rats, Vasodilation, Competitive antagonist, Propargyl, Molecular Medicine, Antipsychotic Agents
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8a6b705eb9d286ac0557fd855eb563Test
https://doi.org/10.1016/j.bmc.2014.04.041Test -
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المؤلفون: Maninder Malik, David E. Reichert, Robert H. Mach, Qi Wang, Yogesh Mishra, Robert R. Luedtke, Shihong Li, Michelle Taylor, Aixiao Li
المصدر: Bioorganic & Medicinal Chemistry. 21:2988-2998
مصطلحات موضوعية: Intrinsic activity, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Phenylpiperazine, Ligands, Binding, Competitive, Biochemistry, Piperazines, Article, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Dopamine receptor D3, Dopamine, Drug Discovery, medicine, Humans, Binding site, Receptor, Molecular Biology, Binding Sites, Receptors, Dopamine D2, Chemistry, Colforsin, Receptors, Dopamine D4, Organic Chemistry, Receptors, Dopamine D3, Molecular Docking Simulation, Dopamine D2 Receptor Antagonists, Kinetics, HEK293 Cells, Dopamine receptor, Adenylyl Cyclase Inhibitors, Dopamine Agonists, Dopamine Antagonists, Molecular Medicine, Adenylyl Cyclases, Protein Binding, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4767cfa608cdcfefcd8d735c32d5abeeTest
https://doi.org/10.1016/j.bmc.2013.03.074Test -
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المؤلفون: Anja Wellejus, Heidi Elbrønd-Bek, Morten Sloth Weidner, Signe Humle Jørgensen, Nicholas M. Kelly
المصدر: Bioorganic & Medicinal Chemistry. 21:3334-3347
مصطلحات موضوعية: Primary Cell Culture, Clinical Biochemistry, Glutamic Acid, Pharmaceutical Science, Biochemistry, Neuroprotection, Piperazines, Capillary Permeability, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, Drug Discovery, Animals, Receptors, sigma, Hydrogen peroxide, Molecular Biology, ADME, Cerebral Cortex, Neurons, Organic Chemistry, Glutamate receptor, Hydrogen Peroxide, Penetration (firestop), Anti-Ulcer Agents, In vitro, Rats, Neuroprotective Agents, chemistry, Blood-Brain Barrier, Molecular Medicine, Pharmacophore, Acyl group, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff76177e7541b18955737ddca691f7b5Test
https://doi.org/10.1016/j.bmc.2013.02.058Test -
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المؤلفون: You-Min Hu, Yong-Yao Cui, Hui-Zhong Liu, Hong-Zhuan Chen, Liang Zhu, Yang Lu, Zhi-Peng Wang, Yin-Yao Niu
المصدر: Bioorganic & Medicinal Chemistry. 21:1234-1239
مصطلحات موضوعية: Male, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Muscarinic Antagonists, Biochemistry, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Ileum, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Heart Atria, Methylene, Molecular Biology, Receptor, Muscarinic M3, Receptor, Muscarinic M2, Organic Chemistry, Absolute configuration, Muscarinic antagonist, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Rats, chemistry, Toxicity, Molecular Medicine, Female, Enantiomer, Tropanes, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88737dec7894229aea4c70e2110246aTest
https://doi.org/10.1016/j.bmc.2012.12.052Test