يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"Muscarinic Antagonists"', وقت الاستعلام: 0.82s تنقيح النتائج
  1. 1
    The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3α-acyloxy-6β-acetoxyltropane derivatives as muscarinic M3 receptor antagonists

    المؤلفون: You-Min Hu, Yong-Yao Cui, Hui-Zhong Liu, Hong-Zhuan Chen, Liang Zhu, Yang Lu, Zhi-Peng Wang, Yin-Yao Niu

    المصدر: Bioorganic & Medicinal Chemistry. 21:1234-1239

    مصطلحات موضوعية: Male, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Muscarinic Antagonists, Biochemistry, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Ileum, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Heart Atria, Methylene, Molecular Biology, Receptor, Muscarinic M3, Receptor, Muscarinic M2, Organic Chemistry, Absolute configuration, Muscarinic antagonist, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Rats, chemistry, Toxicity, Molecular Medicine, Female, Enantiomer, Tropanes, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88737dec7894229aea4c70e2110246aTest
    https://doi.org/10.1016/j.bmc.2012.12.052Test


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  2. 2
    Structure–activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties

    المؤلفون: Carlo Melchiorre, Anna Minarini, Gabriella Marucci, Cristina Bellucci, Vincenzo Tumiatti, Michela Rosini, Carla Ghelardini, Michela Buccioni, Andrea Milelli

    المساهمون: V. Tumiatti, A. Minarini, A. Milelli, M. Rosini, M. Buccioni, G. Marucci, C. Ghelardini, C. Bellucci, C. Melchiorre

    المصدر: Bioorganic & Medicinal Chemistry. 15:2312-2321

    مصطلحات موضوعية: Male, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Photoaffinity Labels, Biochemistry, Mice, Radioligand Assay, chemistry.chemical_compound, Vas Deferens, Cricetinae, Parietal Lobe, Drug Discovery, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor, Polyamines, Methoctramine, Receptor, Cerebral Cortex, Molecular Structure, biology, PAIN, Receptors, Muscarinic, METHOCTRAMINE, Enzyme inhibitor, Acetylcholinesterase, Molecular Medicine, Rabbits, Acetylcholine, medicine.drug, Stereochemistry, Guinea Pigs, CHO Cells, Muscarinic Antagonists, Diamines, Structure-Activity Relationship, Cricetulus, Ileum, medicine, Animals, Humans, Heart Atria, Muscle, Skeletal, Molecular Biology, Acetylcholine receptor, Organic Chemistry, Muscarinic antagonist, Rats, chemistry, Butyrylcholinesterase, Drug Design, biology.protein, Cholinesterase Inhibitors

    وصف الملف: STAMPA

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5d0eaac9e4c5d07218cdcc36b402a4Test
    https://doi.org/10.1016/j.bmc.2007.01.022Test


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  3. 3
    Structure–activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters unexpected agonistic activity in a series of muscarinic antagonists

    المؤلفون: Serena Scapecchi, Fulvio Gualtieri, Rosanna Matucci, Gabriella Marucci, Dina Manetti, Cristina Bellucci, Michela Buccioni, Silvia Dei, Elisabetta Teodori, Maria Novella Romanelli, Piero Angeli

    المصدر: Bioorganic & Medicinal Chemistry. 9:1165-1174

    مصطلحات موضوعية: Atropine, Male, Agonist, Swine, medicine.drug_class, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Phenylpiperazine, Muscarinic Antagonists, In Vitro Techniques, Muscarinic Agonists, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Vas Deferens, Ileum, Drug Discovery, Muscarinic acetylcholine receptor, Agonistic behaviour, medicine, Animals, Receptor, Lung, Molecular Biology, Acetylcholine receptor, Cerebral Cortex, Receptor, Muscarinic M3, Receptor, Muscarinic M2, Chemistry, Myocardium, Receptor, Muscarinic M1, Organic Chemistry, Receptors, Muscarinic, Rats, Alkynes, Molecular Medicine, Rabbits, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df34c2e1dba76684f3a18cb747c64a8aTest
    https://doi.org/10.1016/s0968-0896Test(00)00332-1


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  4. 4
    Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(Acyloxymethyl)-1,3-dioxolanes

    المؤلفون: Livio Brasili, Ugo Gulini, L. Malmusi, Luisa Schenetti, Gabriella Marucci, Adele Mucci

    المصدر: Bioorganic & Medicinal Chemistry. 4:2071-2080

    مصطلحات موضوعية: Male, Models, Molecular, structure characterization, 1H and 13C chemical shifts, Magnetic Resonance Spectroscopy, acyloxymethyl dioxolane, antimuscarinic activity, NMR spectroscopy, Nuclear Overhauser Effect, NOE, coupling constants, Stereochemistry, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Muscarinic Antagonists, Nuclear Overhauser effect, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Vas Deferens, Ileum, Drug Discovery, Animals, Hydroxymethyl, Molecular Biology, Conformational isomerism, Molecular Structure, Chemistry, Myocardium, Chemical shift, Organic Chemistry, Dioxolanes, Nuclear magnetic resonance spectroscopy, Carbon-13 NMR, Molecular Medicine, Rabbits, Selectivity, Cis–trans isomerism

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3452ac8c43f7bfca723e7c287fcb0f1Test
    https://doi.org/10.1016/s0968-0896Test(96)00223-4


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