Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components
| العنوان: | Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components |
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| المؤلفون: | Stylianou, A., Stylianopoulos, T. |
| المساهمون: | Stylianopoulos, T. [0000-0002-3093-1696] |
| المصدر: | BioNanoScience |
| مصطلحات موضوعية: | 0301 basic medicine, Nonlinear optics, Cytoskeleton organization, Mechanical properties, Diseases, Imaging techniques, 02 engineering and technology, Metastasis, Imaging, Extracellular matrix, Atomic force microscopy, Pathology, Biomechanics, cell interaction, Enzyme activity, Extracellular matrices, cancer cell, Cell migration, 021001 nanoscience & nanotechnology, intercellular adhesion molecule 1, Cell biology, Crosstalk (biology), Tumor microenvironment, stroma cell, protein degradation, podosome, 0210 nano-technology, Extracellular matrix, Stromal cells, Fibroblasts, Cell migration, Metastasis, Imaging, Mechanical properties, Second harmonic generation, Coupled AFM, scanning electron microscopy, Operating principles, Materials science, Stromal cell, Cells, Biomedical Engineering, Bioengineering, protein kinase Syk, Article, nerve growth factor, Extracellular matrix interactions, 03 medical and health sciences, medicine, Young modulus, exosome, Stromal cells, Tumors, Harmonic generation, piezoelectricity, cancer growth factor, Second harmonic generation, Fibroblasts, matrix attachment region binding protein, medicine.disease, 030104 developmental biology, Cancer cell, cancer research, Therapeutic strategy, Cell culture, Cytology, Coupled AFM, light related phenomena |
| الوصف: | Cancer cells have different characteristics from normal cells in terms of morphology, cell–cell interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix interactions. Although the clarification of these characteristics is crucial for the effective development of new therapeutic strategies, they remain poorly identified. Furthermore, tumor microenvironment plays a crucial role in cancer progression and metastasis, and thus, it is of utmost importance to decode and fully understand the crosstalk and the interactions between its different components. Atomic force microscopy (AFM) is an established and multifunctional tool in biomedical sciences with many applications in cancer research. In this review, we discuss the use of AFM in the study of cancer cells and the tumor microenvironment. We first provide a brief overview of AFM operating principles highlighting its contribution to the study of cancer and stromal cells. Next, we present research on the use of AFM in the study of cell-tumor microenvironment interactions during cancer cell migration and invasion. Finally, we discuss the development of coupled AFM modalities and the combination of different kinds of imaging with AFM that have been applied to cancer research. © 2015, Springer Science+Business Media New York. 6 33 46 33-46 |
| اللغة: | English |
| تدمد: | 2191-1649 2191-1630 |
| DOI: | 10.1007/s12668-015-0187-4 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd029dc659174577c8d35645f34896d4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd029dc659174577c8d35645f34896d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21911649 21911630 |
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| DOI: | 10.1007/s12668-015-0187-4 |