The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis
| العنوان: | The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis |
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| المؤلفون: | De Shen Wang, Dong Liang Chen, Ying Jin, Dong Sheng Zhang, Rui-Hua Xu, Chao Ren, Fenghua Wang, Liu-Fang Ye, Shaoyan Xi, Ziming Du, Yu Hong Li, Chun-Ping Lin, Feng Wang, Xiao-Meng Ji, Yan-Qing Cai, Zhi Qiang Wang, Miao Zhen Qiu |
| المصدر: | Biomolecules Volume 11 Issue 9 Biomolecules, Vol 11, Iss 1268, p 1268 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Colorectal cancer, Psychological intervention, Kaplan-Meier Estimate, Biochemistry, Microbiology, Article, Metastasis, Cohort Studies, Internal medicine, medicine, Humans, Neoplasm Metastasis, Molecular Biology, Aged, Proportional Hazards Models, business.industry, BRAF V600E, metastatic colorectal cancer, Hazard ratio, Cancer, Retrospective cohort study, Middle Aged, medicine.disease, Confidence interval, QR1-502, digestive system diseases, locoregional interventions, Multivariate Analysis, Mutation, Female, prognosis, heterogeneity, business, Colorectal Neoplasms |
| الوصف: | The prognostic heterogeneity in patients with BRAF V600E metastatic colorectal cancer (mCRC) remains poorly defined. Real-world data of 93 BRAF V600E mCRC patients from Sun Yat-sen University Cancer Center were evaluated using the prognostic factors affecting overall survival (OS). Treatment of metastases served as an independent prognosticator, where curative locoregional interventions (LRIs) were associated with superior clinical outcomes (adjusted hazard ratio (HR): 0.46, 95% confidence interval (CI): 0.22–0.98 p = 0.044). The LRIs group showed an improved median OS of 49.4 months versus 18.3 months for the palliative treatments (PTs) group. The median OS of patients with colorectal liver metastasis (CRLM) was significantly prolonged after undergoing LRIs (42.4 vs. 23.7 months HR: 0.11, 95% CI: 0.01–1.22 p = 0.030), and patients in the LRIs plus liver-limited or lung-limited metastasis (LLM) group benefited more than those in the LRIs plus non-LLM group when compared to the PTs group (LLM from LRIs vs. PTs, HR: 0.16, 95% CI: 0.04–0.68 p = 0.006. Non-LLM from LRIs vs. PTs, HR: 0.47, 95% CI: 0.21–1.05 p = 0.074). In conclusion, we confirmed the positive prognostic value of LRIs in BRAF V600E mCRC, particularly in patients with CRLM or LLM. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-273X |
| DOI: | 10.3390/biom11091268 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea0eef8b2076f24762dc3d0b854bfbbTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eea0eef8b2076f24762dc3d0b854bfbb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
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| DOI: | 10.3390/biom11091268 |