دورية أكاديمية
Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death
| العنوان: | Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death |
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| المؤلفون: | Ge Yu, Daniel J. Klionsky |
| المصدر: | Biomolecules, Vol 12, Iss 7, p 866 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | cellular homeostasis, lysosome, mitophagy, neurodegeneration, stress, Microbiology, QR1-502 |
| الوصف: | Autophagy is a process conserved from yeast to humans. Since the discovery of autophagy, its physiological role in cell survival and cell death has been intensively investigated. The inherent ability of the autophagy machinery to sequester, deliver, and degrade cytoplasmic components enables autophagy to participate in cell survival and cell death in multiple ways. The primary role of autophagy is to send cytoplasmic components to the vacuole or lysosomes for degradation. By fine-tuning autophagy, the cell regulates the removal and recycling of cytoplasmic components in response to various stress or signals. Recent research has shown the implications of the autophagy machinery in other pathways independent of lysosomal degradation, expanding the pro-survival role of autophagy. Autophagy also facilitates certain forms of regulated cell death. In addition, there is complex crosstalk between autophagy and regulated cell death pathways, with a number of genes shared between them, further suggesting a deeper connection between autophagy and cell death. Finally, the mitochondrion presents an example where the cell utilizes autophagy to strike a balance between cell survival and cell death. In this review, we consider the current knowledge on the physiological role of autophagy as well as its regulation and discuss the multiple functions of autophagy in cell survival and cell death. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12070866 2218-273X |
| العلاقة: | https://www.mdpi.com/2218-273X/12/7/866Test; https://doaj.org/toc/2218-273XTest |
| DOI: | 10.3390/biom12070866 |
| الوصول الحر: | https://doaj.org/article/a0936508805e4bc9be484fbd9504d377Test |
| رقم الانضمام: | edsdoj.0936508805e4bc9be484fbd9504d377 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12070866 2218273X |
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| DOI: | 10.3390/biom12070866 |