Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
| العنوان: | Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization |
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| المؤلفون: | Roberta Gonnella, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D'Orazi, Maria Anele Romeo, Marisa Granato, C. Zompetta, Mara Cirone, Alberto Faggioni |
| المصدر: | Biomolecules, Vol 9, Iss 9, p 482 (2019) Biomolecules Volume 9 Issue 9 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, autophagy, Epstein-Barr virus (EBV), IL-6, LCLs, quercetin, ROS, SQSTM1/p62, STAT3, Epstein-Barr Virus Infections, viruses, lcsh:QR1-502, medicine.disease_cause, Biochemistry, lcsh:Microbiology, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Sequestosome-1 Protein, heterocyclic compounds, Cells, Cultured, Feedback, Physiological, chemistry.chemical_classification, B-Lymphocytes, biology, Chemistry, virus diseases, respiratory system, Cell biology, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Quercetin, STAT3 Transcription Factor, Cell Survival, Article, 03 medical and health sciences, medicine, Animals, Humans, Molecular Biology, B cell, Reactive oxygen species, Interleukin-6, Autophagy, Epstein–Barr virus (EBV), STAT3, biochemical phenomena, metabolism, and nutrition, Cell Transformation, Viral, 030104 developmental biology, Cell culture, STAT protein, biology.protein, Reactive Oxygen Species, Carcinogenesis |
| الوصف: | The oncogenic gammaherpesvirus Epstein&ndash Barr virus (EBV) immortalizes in vitro B lymphocytes into lymphoblastoid cell lines (LCLs), a model that gives the opportunity to explore the molecular mechanisms driving viral tumorigenesis. In this study, we addressed the potential of quercetin, a widely distributed flavonoid displaying antioxidant, anti-inflammatory, and anti-cancer properties, in preventing EBV-driven B cell immortalization. The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process. Moreover, we found that quercetin promoted autophagy and counteracted the accumulation of sequestosome1/p62 (SQSTM1/p62), ultimately leading to the prevention of B cell immortalization. These findings suggest that quercetin may have the potential to be used to counteract EBV-driven lymphomagenesis, especially if its stability is improved. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caa4a7edb646dbbc0c444d705ba95f0Test https://www.mdpi.com/2218-273X/9/9/482Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3caa4a7edb646dbbc0c444d705ba95f0 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |